Abstract
2,6-Diamino-8-arylpurines were obtained by condensation of 2,4,5,6-tetraaminopyrimidine with aromatic aldehydes with nitrobenzene as the oxidizing agent in the presence of p-toluenesulfonic acid or divalent copper.
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Literature cited
G. B. Elion, G. H. Hitchings, and H. Vanderwerf, J. Biol. Chem., 192, 505 (1951).
G. H. Hitchings and G. B. Elion, US Patent No. 2,628,235 (1953); Chem. Atastr., 48, 713 (1954).
B. R. Baker, Design of Active-Site-Directed Irreversible Enzyme Inhibitors, New York (1967), p. 229.
B. R. Baker and D. V. Santi, J. Heterocycl. Chem., 4, 216 (1967).
S. C. J. Fu and E. Chinoporos, J. Heterocycl. Chem., 3, 476 (1966).
R. Weidenhagen, Ber., 69, 2263 (1936).
D. Jerchel, M. Kracht, and K. Krucker, Ann., 590, 232 (1954).
W. Traube and W. Nithak, Ber., 39, 227 (1906).
C. K. Cain, M. F. Mallette, and E. C. Taylor, J. Am. Chem. Soc., 69, 1814 (1947).
R. K. Grantham and O. Meth-Cohn, J. Chem. Soc., C, 1444 (1969).
A. V. El'tsov, M. Z. Girshovich, and Kh. L. Muravich-Aleksandr, Zh. Organ. Khim., 5, 558 (1969).
B. R. Baker, D. V. Santi, J. K. Coward, H. S. Shapiro, and J. H. Jordaan, J. Heterocycl. Chem., 3, 425 (1966).
I. J. Pachter, J. Org. Chem., 28, 1191 (1963).
S. L. Shapiro, H. Soloway, and L. Freedman, J. Am. Chem. Soc., 80, 2473 (1958).
G. B. Crippa and S. Maffei, Gazz. Chim. Ital., 71, 194 (1941).
H. Zellner and G. Zellner, Helv. Chim. Acta, 49, 913 (1966).
L. Kurlansik and E. F. Salim, J. Pharm. Sci., 55, 1457 (1966).
G. B. Elion, E. Burgi, and G. H. Hitchings, J. Am. Chem. Soc., 73, 5235 (1951).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1430–1434, October, 1972.
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Kuznetsov, V.S., Remizov, A.L. Synthesis of 2, 6-diamino-8-arylpurines using aromatic aldehydes. Chem Heterocycl Compd 8, 1292–1297 (1972). https://doi.org/10.1007/BF00475551
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DOI: https://doi.org/10.1007/BF00475551