Abstract
The synthesis of oxo derivatives of pyrrolo[3, 4-d]pyrimidine has been effected by the reaction of the lactone of 5-(hydroxymethyl)-orotic acid with ammonia or primary amines. In a number of cases, in place of the free organic bases their salts with mineral acids were used successfully. A number of 2, 4, 7-trioxo derivatives of pyrrolo[3, 4-d]pyrimidine and some new derivatives of orotic acid have been synthesized.
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Britikova, N.E., Metel'kova, E.I., Chkhikvadze, K.A. et al. Derivatives of orotic acid and its analogs. Chem Heterocycl Compd 3, 848–851 (1967). https://doi.org/10.1007/BF00474888
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DOI: https://doi.org/10.1007/BF00474888