Abstract
By fusion with potassium hydroxide, derivatives of 1-aryl-3-ethoxycarbonyl-5-methoxy-2-methylindole are converted into the corresponding indole-3-carboxylic acids. When the indole-3-carboxylic acids are heated to their melting points, they are readily converted into derivatives of 1-arylindoles with unsubstituted β-positions. A similar cycle of conversions has been carried out for 3-ethoxycarbonyl-5-methoxy-2-methyl-1-phenylbenzoindole. The reactions of derivatives of 1-aryl-5-methoxy-2-methylindoles with formaldehyde and dimethylamine hydrochloride gives Mannich bases.
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Grinev, A.N., Shvedov, V.I. & Panisheva, E.K. Derivatives of 1-aryl-5-methoxyindoles. Chem Heterocycl Compd 3, 822–824 (1967). https://doi.org/10.1007/BF00474880
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DOI: https://doi.org/10.1007/BF00474880