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Action of alkali metals in liquid ammonia on substituted thiophenes

III. Preparation of amino ketones of the aliphatic series from 2-(ω-dialkylaminoalkyl)thiophenes

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The action of lithium and alcohols in liquid ammonia on α-substituted thiophenes with subsequent hydrolysis of the products leads to conversion of the thiophene fragment of the molecule to a butyryl group. A number of amino ketones of the aliphatic series were obtained from α-(ω-dialkylaminoalkyl)thiophenes.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    Ya. L. Gol'dfarb & E. P. Zakharov

Authors
  1. Ya. L. Gol'dfarb
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  2. E. P. Zakharov
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Additional information

See [1] for communication II.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1499–1502, November, 1975.

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Gol'dfarb, Y.L., Zakharov, E.P. Action of alkali metals in liquid ammonia on substituted thiophenes. Chem Heterocycl Compd 11, 1277–1280 (1975). https://doi.org/10.1007/BF00474453

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  • DOI: https://doi.org/10.1007/BF00474453

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