Abstract
Bromination of 1-methylpiperidine-4-carboxaldehyde gave 4-bromo-1-methylpiperidine-4-carboxaldehyde hydrobromide which was used to synthesize 1,4,9-triazaspiro[5,5]undecane and 3,7,11-triazaspiro[5,6]dodecane. Cyanoethylation and alkylation with various alkyl halides gave their mono- and di-substituted derivatives. The side chain nitrile group was reduced and the hydrazide was obtained from the ester analog.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1673–1676, December, 1986.
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Kuroyan, R.A., Sarkisyan, V.V. & Vartanyan, S.A. Synthesis and properties of 1,4,9-triazaspiro[5,5]undecane and 3,7,11-triazaspiro[5,6]dodecane. Chem Heterocycl Compd 22, 1354–1357 (1986). https://doi.org/10.1007/BF00474359
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DOI: https://doi.org/10.1007/BF00474359