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Synthesis of 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones by reformatsky reaction

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Abstract

Methyl 1-bromocyclohexanecarboxylate reacted with zinc and aromatic aldehydes in two steps to afford 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones; methyl 1-[aryl(hydroxy)methyl]cyclohexanecarboxylates were also formed as by-products.

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Authors and Affiliations

  1. Perm State National Research University, ul. Bukireva 15, Perm, 614990, Russia

    N. F. Kirillov, E. A. Nikiforova, A. N. Vasyanin & M. V. Dmitriev

Authors
  1. N. F. Kirillov
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  2. E. A. Nikiforova
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  3. A. N. Vasyanin
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  4. M. V. Dmitriev
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Correspondence to N. F. Kirillov.

Additional information

Original Russian Text © N.F. Kirillov, E.A. Nikiforova, A.N. Vasyanin, M.V. Dmitriev, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 4, pp. 530–534.

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Kirillov, N.F., Nikiforova, E.A., Vasyanin, A.N. et al. Synthesis of 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones by reformatsky reaction. Russ J Org Chem 51, 513–517 (2015). https://doi.org/10.1134/S1070428015040089

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  • DOI: https://doi.org/10.1134/S1070428015040089

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