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Lactam and amide acetals. 52. Reaction of dimethylformamide diethylacetal with 2,2-dimethyl-4,6-dioxo-1,3-dioxane (Meldrum's acid)

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Depending on the conditions of carrying out the reaction of dimethylformamide diethylacetal with the Meldrum's acid, either 2,2-dimethyl-4,6-dioxo-5-(N,N-dimethyl-aminomethylene)-1,3-dioxane or N,N,N1N1-tetramethylformamidinium salt of 2,2-dimethyl-4,6-dioxo-5-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)methylene-1,3-di-oxane are formed. The two compounds can react with primary amines to form N-substituted 2,2-dimethyl-4.,6-dioxo-5-aminomethylene-1,3-dioxanes.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific Research Chemical Pharmaceutical Institute, 119021, Mscow

    T. V. Stezhko, N. P. Solov'eva, E. F. Kuleshova & V. G. Granik

Authors
  1. T. V. Stezhko
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  2. N. P. Solov'eva
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  3. E. F. Kuleshova
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  4. V. G. Granik
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Additional information

For Communication 51, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 184–187, February, 1988.

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Stezhko, T.V., Solov'eva, N.P., Kuleshova, E.F. et al. Lactam and amide acetals. 52. Reaction of dimethylformamide diethylacetal with 2,2-dimethyl-4,6-dioxo-1,3-dioxane (Meldrum's acid). Chem Heterocycl Compd 24, 151–153 (1988). https://doi.org/10.1007/BF00473322

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  • DOI: https://doi.org/10.1007/BF00473322

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