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Effect of the reaction conditions on the character of the products of acetylation of 2-methylmercapto-, 2-methoxy-, and 2-dimethylaminothiophene

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Acetylation of 2-methylmercaptothiophene by the action of acetyl chloride in methylene chloride at −70°C in the presence of excess AlCl3 gives a mixture of 5-methylmercapto-2-acetylthiophene, 5-methylmercapto-2,4-diacetylthiophene, and a small amount of 3-acetyl-substituted derivative. The acetylation of 2-methoxythiophene gives similar results. 5-Dimethylamino-2-acetylthiophene was obtained from 2-dimethylaminothiophene under similar conditions.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    N. S. Ksenzhek, L. I. Belen'kii & Ya. L. Gol'dfarb

Authors
  1. N. S. Ksenzhek
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  2. L. I. Belen'kii
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  3. Ya. L. Gol'dfarb
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 486–489, April, 1973.

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Ksenzhek, N.S., Belen'kii, L.I. & Gol'dfarb, Y.L. Effect of the reaction conditions on the character of the products of acetylation of 2-methylmercapto-, 2-methoxy-, and 2-dimethylaminothiophene. Chem Heterocycl Compd 9, 447–450 (1973). https://doi.org/10.1007/BF00471521

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  • DOI: https://doi.org/10.1007/BF00471521

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