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Synthesis of pyrimidyl-N1-α-amino acids

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

β-(5-Fluoro-N1-uracilyl)-α-alanine, β-(5-bromo-N1-uracilyl)-α-alanine, β-(5-chloro-N1-uracilyl)-α-alanine, β-(N1-thyminyl)-α-alanine, β-(N1-cytosinyl)-α-alanine, β-(2-oxo-4-carboxymethylamino-1, 2-dihydro-N1-pyrimidyl)-α-alanine, γ-(N1-uracilyl)-α-aminobutyric acid, γ-(N1-thyminyl)-α-aminobutyric acid, and γ-(N1-cytosinyl)-α-aminobutyric acid were synthesized by the reactions involving the cyanohydrin synthesis and other transformations. In addition, a number of substituted N1-pyrimidylacetaldehydes and N1pyrimidylpropionaldehydes and their diethylacetals were synthesized.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the LatvianSSR, Riga

    M. Yu. Lidak, R. A. Paégle, M. G. Plata & Yu. P. Shvachkin

  2. M. V. Lomonosov Moscow State University, USSR

    M. Yu. Lidak, R. A. Paégle, M. G. Plata & Yu. P. Shvachkin

Authors
  1. M. Yu. Lidak
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  2. R. A. Paégle
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  3. M. G. Plata
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  4. Yu. P. Shvachkin
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 530–534, April, 1971.

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Lidak, M.Y., Paégle, R.A., Plata, M.G. et al. Synthesis of pyrimidyl-N1-α-amino acids. Chem Heterocycl Compd 7, 494–498 (1971). https://doi.org/10.1007/BF00471493

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  • DOI: https://doi.org/10.1007/BF00471493

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