Abstract
The reaction of dimethylformamide diethylacetal with α-cyano-β-dimethylaminoacrylamide proceeds at the NH2 amide group to give the corresponding acylformamidine, from which 3-cyano-4-dimethylamino-2-pyridone was obtained by thermal cyclization. Pyrrolo-, pyrido-, and azepino-[3,2-c]pyridine derivatives were similarly synthesized from 1-methyl-2-(2′-cyano-2′-carbamido)-methylenepyrrolidine and the homologous six- and seven-membered enaminoamides.
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See [1] for communication XVII.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1509–1512, November, 1976.
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Granik, V.G., Marchenko, N.B., Vlasova, T.F. et al. Acetals of lactams and acid amides. Chem Heterocycl Compd 12, 1243–1245 (1976). https://doi.org/10.1007/BF00470223
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DOI: https://doi.org/10.1007/BF00470223