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Acetals of lactams and acid amides. XV. Reaction of acetals of N, N-dimethyl- and N-methyl-N-(β-carbethoxyethyl)acetamides with ethyl anthranilate and synthesis of 4-quinolone and 4-quinazolone derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

N, N-Dimethyl- and N-methyl-N-(β-carbethoxyethyl)-N1-(o-carbethoxyphenyl) acetamidines were synthesized by reaction of diethylacetals of N, N-dimethyl- and N-methyl-N-(β-carbethoxyethyl) acetamides with ethyl anthranilate. The thermal cyclization of these amidines proceeds in different ways — 2-dimethylamino-4-quinolone is formed in the first case, and 2, 3-dimethyl-4-quinazolone is formed in the second.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow

    N. B. Marchenko, V. G. Granik, T. F. Vlasova, O. S. Anisimova & R. G. Glushkov

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  1. N. B. Marchenko
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  2. V. G. Granik
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  3. T. F. Vlasova
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  4. O. S. Anisimova
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  5. R. G. Glushkov
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Additional information

See [1] for communication XIV.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5 pp. 665–668, May, 1976.

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Marchenko, N.B., Granik, V.G., Vlasova, T.F. et al. Acetals of lactams and acid amides. XV. Reaction of acetals of N, N-dimethyl- and N-methyl-N-(β-carbethoxyethyl)acetamides with ethyl anthranilate and synthesis of 4-quinolone and 4-quinazolone derivatives. Chem Heterocycl Compd 12, 559–562 (1976). https://doi.org/10.1007/BF00470112

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  • DOI: https://doi.org/10.1007/BF00470112

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