Summary
The response of the nasal mucous membrane to anti-human IgE serum was examined. The application of anti-IgE sera to the nasal mucous membrane induced a nasal allergy-like symptom as well as nasal eosinophilia. This symptom was observed in the majority of nasal allergy cases and in some vasomotor rhinitis cases, while not in non-allergic normal persons. The nasal eosinophilia, however, increased not only in allergic patients, but in non-allergic persons in whom no nasal symptoms were induced. Such a nasal reaction was not induced with anti-IgA sera or anti-IgG sera. The character of the reaction was presumed to be specific to anti-IgE and was predominantly a reversed type anaphylaxis in the nasal mucous membrane. The sensitivity of the nasal mucous membrane to anti-IgE decreased in the course of the hyposensitization with house dust. The cause of this phenomenon was obscure.
Zusammenfassung
Durch Berührung des Anti-Menschen-IgE-Serums auf die Oberfläche der Nasenschleimhaut treten allergieartige Symptome und Lokaleosinophilie auf. Solche Symptome findet man meistens bei Fällen von Nasenallergie und in wenigen Fällen der sogenannten vasomotorischen Rhinitis, aber man findet sie nicht bei nichtallergischen Patienten. Die Naseneosinophilie tritt nicht nur bei allergischen Patienten, sondern auch bei nichtallergischen Patienten auf, die bei der obigen Berührung keine Symptome gehabt haben. Solche Nasenreaktionen waren aus Anti-Menschen-IgA-Serum oder -Anti-IgG-Serum nicht hervorgegangen.
Der Charakter der Reaktion ist spezifisch für Anti-IgE-Serum, und hauptsächlich denkt man an Reaktion “reversed type anaphylaxis” in der Nasenschleimhaut.
Die Sensibilität der Nasenschleimhaut zur Anti-IgE nimmt während der Hyposensitisation durch Hausstauballergien ab. Der Grund dieses Phänomens ist unklar.
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Okuda, M. Response of the human nasal mucous membrane to anti-human IgE serum. Arch Otorhinolaryngol 211, 25–33 (1975). https://doi.org/10.1007/BF00467287
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DOI: https://doi.org/10.1007/BF00467287