Summary
The ability of the liver to metabolise insulin in response to varying blood insulin levels was studied using normally fed, starved and streptozotocin diabetic rats. Insulin clearance by the livers of fasted and diabetic rats was significantly increased compared with normal fed controls. Administration of insulin to diabetic animals prior to liver perfusion, or an increase in the concentration of the hormone in the perfusion medium used for normal livers resulted in a significant decrease in clearance. The percentage uptake of insulin during single passage through the livers of starved and diabetic animals was significantly greater than normal.
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McCarroll, A.M., Buchanan, K.D. Insulin clearance by the isolated perfused livers of insulin deficient rats. Diabetologia 9, 457–460 (1973). https://doi.org/10.1007/BF00461688
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DOI: https://doi.org/10.1007/BF00461688