Summary
The investigation of 400 adult mice had the objective to find out
-
1.
The influence of splenectomy on genesis and growth of a benzpyrene-induced sarcoma and
-
2.
The behavior of B- and T-lymphocytes under the influence of splenectomy.
Results
-
1.
A significantly lower number of tumors developed in splenectomized animals (28.5%) as compared to controls (49.5%).
-
2.
A significant decrease of B-lymphocytes and an increase in T cells after splenectomy were found in the peripheral blood.
-
3.
The examination of the tumor marginal zone showed a drecreased number of B-lymphocytes and an increase of T-lymphocytes, while the total count of round cells remained unchanged.
These results are discussed and compared with results of other authors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Böyum, A.: Isolation of leukocytes from human blood Scand. J. clin. lab. Invest. 21 (Suppl. 98), 9–89 (1968)
Brüda, B. E.: Über erfolgreiche Züchtung von Mäusetumoren auf entmilzten Ratten. Klin. Wschr. 7, 27 (1928)
Chang, R. W.S., Turk, J.L.: Increased resistance in splenectomized mice to a methylcholanthrene-induced tumor. Brit. J. Cancer 35, 768–776 (1977)
Danielson, J.R., Alten, P.J. van: Lymphocyte proliferation inhibited by cells and by effector substances obtained from bursal lymphocytes. Tumor Res. 19, 194–202 (1974)
Gershon, R.K., Cohen, P., Hencin, R., Liebhaber, S.A.: Suppressor T-cells. J. Immunol. 108, 586–590 (1972)
Grebe, S.C., Streilein, J.W.: Graft-versus-host reactions: a review. Advanc. Immunol. 22, 119–221 (1976)
Hagmann, J., Hess, M. W., Keller, H.U., Cottier, H.: Cell systems participating in graft rejections. In: Masshoff, J. W. (Ed.): Transplantation Handbuch der allgemeinen Pathologie, Band 6, Teil 8. Berlin, Heidelberg, New York: Springer 1977
Lennert, K.A., Saenger, M.D., Mondorf, W.: Splenektomie-bedingte Spätveränderungen. Münch. Med. Wschr. 111, 190–197 (1969)
Lewin, H., Gericke, D.: Über die Wirkung der Milzexstirpation auf das Wachstum transplantabler Rattentumoren. Naturwissenschaften 61, 509–510 (1974)
Lozzio, B. B., Wargon, L. B.: Immune competence of hereditarily asplenic mice Immunology 27, 167–178 (1974)
Nie, N.N., Hull, C.H., Jenkins, J.G., Steinbrenner, K., Bent, D.H.: Statistical Package for the Social Sciences (SPSS) McGraw-Hill Book Company, Second Edition 1975
Niedorf, H.R.: Das lymphatische Gewebe des Hühnchens nach Bursektomie und bei experimenteller Onkogenese. Habilitationsschrift der Westfälischen Wilhelms-Universität Münster 1975
Raff, M.C., Owen, J. J.T.: Thymus-derived lymphocytes: their distribution and role in the development of peripheral lymphoid tissues of the mouse. Eur. J. Immunol. 1, 27–30 (1971)
Stone, H.H., Stanley, D.G., de Jarnette, R.H.: Postsplenectomy viral hepatitis. J. Amer. med. Ass. 199, 851–853, 1967
Suter, E.R., Probst, H., Dukor, P.: The fine structure of complement-receptor lymphocytes in mice. Eur. J. Immunol. 2, 189–190, 1972
Whitney, R.B., Pope, B.L., Levy, J.G.: Immune competence and immunosuppressive factors in splenectomized tumor-bearing mice. Cell. Immunol. 28, 15–21 (1977)
Witting, Ch., Hultsch, E.: Effect of generalized graft-versus-host-reaction on B-and T-lymphocytes and a benzpyrene-induced murine sarcoma. Z. Krebsforsch, (in prep.)
Author information
Authors and Affiliations
Additional information
Supported by Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen
Rights and permissions
About this article
Cite this article
Witting, C., Hultsch, E. Effect of splenectomy on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma. Z. Krebsforsch. 92, 267–274 (1978). https://doi.org/10.1007/BF00461649
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00461649