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Experimental parathyroiditis in the rat by passive immunisation

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Summary

By immunisation of rabbits with rat parathyroid-(PTG)-homogenates or bovine PTG-homogenates antisera with species- and organ-specific antibodies against rat PTG or bovine PTG, respectively, have been produced. After passive immunisation of rats with the antiserum against rat PTG a marked immunoparathyroiditis developed in three out of 15 rats. Hypoparathyroidism, however, was not observed.

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References

  • Blizzard, R.M., Chee, D., Davis, W. G.: Idiopathic hypoparathyroidism: a probable autoimmune disease. J. Pediat. 69, 969 (1966a)

    Google Scholar 

  • Blizzard, R.M., Chee, D., Davis, W. G.: The incidence of parathyroid and other antibodies in the sera of patients with idiopathic hypoparathyroidism. Clin. exp. Immunol. 1, 119–128 (1966b)

    Google Scholar 

  • Casseye, M. van de, Gepts, W.: Primary (autoimmune?) parathyroiditis. Virchows Arch. Abt. A 361, 257–261 (1973)

    Google Scholar 

  • Craig, J.M., Schiff, L.H., Boone, J.E.: Chronic moniliasis associated with Addison's disease. Amer. J. Dis. Child. 89, 669–684 (1955)

    Google Scholar 

  • Jancovic, B.D., Isvaneski, M., Ljuhjana, P., Mitrovic, K.: Experimental allergic thyroiditis (and parathyroiditis) in neonatally thymectomized and bursectomized chickens. Int. Arch. Allergy 26, 18–33 (1965)

    Google Scholar 

  • Klöppel, G., Altenähr, E., Freytag, G.: Studies on ultrastructure and immunology of the insulitis in rabbits immunised with insulin. Virchows Arch. Abt. A 356, 1–15 (1972)

    Google Scholar 

  • Koessling, F. K., Emmrich, P.: Demonstration eines Falles von kindlichem Morbus Addison und Hypoparathyreoidismus. Verh. dtsch. Ges. Path. 55, 155–160 (1971)

    Google Scholar 

  • Lupulescu, A., Petrovici, A., Pop, A., Heitmanek, C.: Electron microscopic observations on the parathyroid gland in experimental hypoparathyroidism. Experientia (Basel) 24 (I), 62–63 (1968)

    Google Scholar 

  • Lupulescu, A., Pop, A., Merculiev, E., Neacsu, C., Heitmanek, C.: Experimental isoimmune hypoparathyroidism in rats. Nature (Lond.) 206, 415–416 (1965)

    Google Scholar 

  • Lupulescu, A., Potorac, E., Pop, A., Heitmanek, C., Merculiev, E., Chisiu, N., Oprisan, R., Neacsu, C.: Experimental investigations on immunology of the parathyroid gland. Immunology 14, 475–482 (1968)

    Google Scholar 

  • Mitschke, H., Altenähr, E., Delling, G., Wiebel, J.: Das plurigladuläre Insuffizienzsyndrom Hypoparathyreoidismus — Morbus Addison — Moniliasis. Dtsch. med. Wschr. 98, 1666–1669 (1973)

    Google Scholar 

  • Ouchterlony, O.: Diffusion-in-gel methods for immunological analysis. Progr. Allergy 5, 1–8 (1958)

    Google Scholar 

  • Reiner, L., Klayman, M. J., Cohen, R. B.: Lymphocytic infiltration of the parathyroid glands. Jew. mem. Hosp. Bull. (N.Y.) 7, 103–117 (1962)

    Google Scholar 

  • Seemann, N.: Untersuchungen zur Häufigkeit der lymphocytären Parathyreoiditis. Dtsch. med. Wschr. 92, 106–108 (1967)

    Google Scholar 

  • Witebsky, H., Rose, N.R.: Chronic thyroiditis and autoimmunization. J. Amer. med. Ass. 164, 1439–1447 (1957)

    Google Scholar 

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Supported by DFG, Sonderforschungsbereich 34 “Endokrinologie”.

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Altenähr, E., Jenke, W. Experimental parathyroiditis in the rat by passive immunisation. Virchows Arch. A Path. Anat. and Histol. 363, 333–342 (1974). https://doi.org/10.1007/BF00447844

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