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Malignes Histiocytom der Haut mit multivesiculärer Vacuolisierung

Multivesicular vacuolization in malignant histiocytoma of the skin

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Summary

A 47-year-old patient developed several rapidly growing tumours in his right leg. Histologic and electron microscopic examination revealed morphological characteristics suggesting the histiocytic origin of the tumour cells. An important finding was the striking number of pleomorphic membraneous inclusions and large vacuoles containing numerous small vesicles. These cytoplasmic inclusions are interpreted as transformed multivesicular bodies. Their formation may be an expression of an increased and bizarre membraneous activity of a malignant cell race. Radiotherapy resulted in a remarkably rapid and complete remission.

Zusammenfassung

Bei einem 47 jährigen Patienten entwickelten sich am rechten Bein mehrere rasch wachsende Tumoren von distal nach proximal. Histologisch und elektronenmikroskopisch zeigten die Tumorzellen morphologische Besonderheiten, die für ihre histiocytäre Provenienz sprechen. Auffallend war die große Anzahl polymorpher cytoplasmatischer Membranstrukturen und großer Vacuolen, die massenhaft kleine Vesikel enthielten. Diese Strukturen werden als transformierte multivesiculäre Körper gedeutet; ihre Entstehung vollzieht sich im Rahmen einer bizarr übersteigerten Membranaktivierung einer malignen Zellrasse. Bemerkenswert ist die rasche und völlige Remission durch Radiotherapie.

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Authors and Affiliations

  1. Hautklinik der Universität Bonn, D-5300, Bonn-Venusberg, Bundesrepublik Deutschland

    Heinz Werner Seifert & Georg Klingmüller

  2. Pathologisches Institut der Universität Bonn, D-5300, Bonn-Venusberg, Bundesrepublik Deutschland

    Klaus Tschubel

Authors
  1. Heinz Werner Seifert
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  2. Georg Klingmüller
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  3. Klaus Tschubel
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Additional information

Auszugsweise vorgetragen beim 4th European Meeting on Electron Microscopy Applied on Cutaneous Pathology, Heidelberg, 6. und 7. Mai 1977: “Multivesicular Vacuolization in Malignant Histiocytoma”.

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Seifert, H.W., Klingmüller, G. & Tschubel, K. Malignes Histiocytom der Haut mit multivesiculärer Vacuolisierung. Arch Dermatol Res 261, 163–173 (1978). https://doi.org/10.1007/BF00447161

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  • DOI: https://doi.org/10.1007/BF00447161

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