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T and B lymphocytes in vitiligo

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Summary

Lymphocyte subpopulations were studied in 38 patients with vitiligo and in 44 controls. No significant differences in the results of several immunological examinations (E-RFC, EAC-RFC, EA-RFC, IF, IF-elution) came to light results suggest that the lymphocytes are probably not implied in the pathogenesis of vitiligo.

Zusammenfassung

Die Lymphocytenpopulation wurde in 38 Patienten mit Vitiligo und 44 Kontrollen untersucht. Es wurden keine signifikanten Unterschiede bei den verschiedenen immunologischen Untersuchungen festgestellt (E-RFC, EAC-FRC, EA-RFC, IF, IF-elution) und es wird damit deutlich, daß die Lymphocyten offenbar nicht an den Vorgängen der Vitiligo beteiligt sind.

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References

  1. Aiuti, F., Cerottini, J. C., Coombs, R. R. A., Cooper, M., Dickler, H. B., Froland, S. S., Fudenberg, H. H., Greaves, M. F., Grey, H. M., Kunkel, H. G., Natvig, J. B., Preud'home, J. F., Pabellino, E., Ritts, R. E., Rowe, D. S., Seligmann, M., Siegel, F. P., St Jernsward, J., Terry, W. D., Wybran, J.: Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood. Report WHO/IARC, sponsored workshop on human B and T cells. London 15–17 July 1974, Scand. J. Immun. 3, 521–532 (1974)

    Google Scholar 

  2. Basten, A., Miller, J. F., Sprent, J., Pye, J.: A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J. exp. Med. 135, 610–618 (1972)

    Google Scholar 

  3. Bianco, C., Patrick, R., Nussenzweig, V.: A population of lymphocytes bearing a membrane receptor for antigen antibody complement complexes. I. Separation and characterization. J. exp. Med. 132, 702–720 (1970)

    Google Scholar 

  4. Boyum, A.: Separation of leucocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21, Suppl. 97, 77–89 (1968)

    Google Scholar 

  5. Brostoff, J., Bor, S., Feiwel, M.: Vitiligo and autoimmunity. Lancet 1969II, 177–178

  6. Char, D. H., Brunn, J. B., West, W.: Thymus-derived lymphocytes in the Vogt-Koyanagi-Harada syndrome. Invest. Opht. Vis. Sci. 16, 179–181 (1977)

    Google Scholar 

  7. Copeman, P. W. M., Lewis, M. G., Bleehen, S. S.: Biology and immunology of vitiligo and cutaneous malignant melanoma. In: A. Rook, Recent Advances in Dermatology, Edinburgh and London: Churchill Livingstone p. 245–284

  8. Forni, L., Pernis, B.: Interaction between Fc receptors and membrane immunoglobulins on B lymphocytes. In: Membrane receptors of lymphocytes. Inserm Symp. 1, 193–201 (1975)

  9. Froland, S. S., Natvig, J. B.: Identification of three different lymphocyte population by surface markers. Transpl. Rev. 16, 114–162 (1973)

    Google Scholar 

  10. Hertz, K. C., Gazze, L. A., Kirkpatrick, C. H., Katz, S. I.: Autoimmune vitiligo. Detection of antibodies to melanin producing cells. New Engl. J. Med. 297, 634–637 (1977)

    Google Scholar 

  11. Huber, H., Polley, J. M., Linscott, W. D., Fudenberg, H. H., Muller-Eberhard, H. J.: Human monocytes: distinct receptor sites for the third component of complement and for IgG. Science 162, 1281–1282 (1968)

    Google Scholar 

  12. Kumagai, K., Abo, T., Sekiza, Wa. T., Sasaki, M.: Studies of surface immunoglobins on human B lymphocytes. I. Dissociation of cell-bound immunoglobulins with acid pHoz at 37°C. J. Immun. 115, 892–987 (1975)

    Google Scholar 

  13. Langhof, H., Feuerstein, M., Schabinski, G.: Melaninati korperbilding bei vitiligo. Hautarzt 16, 209–212 (1965)

    Google Scholar 

  14. Lerner, A. B.: On the aetiology of vitiligo and grey hair. Amer. J. Med. 51, 141–147 (1971)

    Google Scholar 

  15. Lobo, P. I., Westervelt, F. B., Horwitz, D. A.: Identification of two populations of immunoglobulin bearing lymphocytes in man. J. Immun. 114, 116–119 (1975)

    Google Scholar 

  16. Vossen, J. M., Hijman, S. W.: Membrane associated immunoglobulin determinants on bone marrow and blood lymphocytes in the pediatric age group and on foetal tissues. N. Y. Acad. Sci. 254, 262–278 (1975)

    Google Scholar 

  17. Wybran, J., Carr, M. C., Fudenberg, H. H.: The human rosette forming cells as a marker of a population of thymus-derived cells. J. Clin. Invest. 51, 2537–2542, (1972)

    Google Scholar 

  18. Wybran, J., Fudenberg, H. H.: Thymus derived rosette forming cells. New Engl. J. Med. 288, 1072–1073 (1973)

    Google Scholar 

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Authors and Affiliations

  1. F. R. A. Inserm N° 11 “Recherche Dermatologique et Immunologie”, Hôpital Edouard Herriot, F-69374, Lyon Cédex 2, France

    J. P. Ortonne & A. Alario

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  1. J. P. Ortonne
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  2. A. Alario
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The technical assistance of Miss M. Chaix is gratefully acknowledged

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Ortonne, J.P., Alario, A. T and B lymphocytes in vitiligo. Arch Dermatol Res 261, 147–151 (1978). https://doi.org/10.1007/BF00447159

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  • DOI: https://doi.org/10.1007/BF00447159

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