Abstract
A 22 years old female with the late-onset type of argininosuccinic aciduria was successfully treated for 5 months with a mixture of essential amino acids and their keto-analogues. There was a marked change in plasma ammonia, plasma amino acids and argininosuccinic acid excretion. A long term anabolic response was reflected by an increase of total serum proteins and serum albumin by about 1 g/dl during the first 5 months of treatment. There was a striking improvement in the patient's seizure disorder following institution of the keto-analogue therapy.
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Böhles, H., Heid, H., Harms, D. et al. Argininosuccinic aciduria: Metabolic studies and effects of treatment with keto-analogues of essential amino acids. Eur J Pediatr 128, 225–233 (1978). https://doi.org/10.1007/BF00445607
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DOI: https://doi.org/10.1007/BF00445607