Summary
Nine sand rats maintained on a high fat diet gained weight, developed endogenous hyperinsulinaemia and resistance to exogenous insulin without further deterioration in glucose tolerance. A four hour post glucose hyperinsulinaemia, noted in some animals on both diets, may represent a chronic stress to the islets in these intermittent feeders. Five animals survived post lesion. Results were consistent with previous findings that lesions in the posterior median eminence portion of the periventricular arcuate system were associated with an improved glucose tolerance, and also in the present study, an increased sensitivity to exogenous insulin. A possible explanation for the mechanism of these effects on carbohydrate metabolism is suggested.
Résumé
Neuf rats des sables soumis à un régime très riche en graisses ont pris du poids, montré une hyperinsulinémie endogéne et une résistance à l'insuline exogène sans autre modification de la tolérance au glucose — Quelques animaux soumis aux deux régimes ont montré une hyperinsulinémie quatre heures après l'absorption de glucose, dont la signification pourrait être un stress des îlots dû à l'intermittence des prises alimentaires — Cinq animaux ont survécu après lésion — Les résultats confirment les précédents: les lésions de la partie postérieure de l'éminence médiane du périventricularis sont liées à une amélioration de la tolérance au glucose, ainsi, comme le montre cette étude, qu' à une augmentation de la sensibilité à l' insuline exogène. Une hypothèse sur les mécanismes de ces effets sur le métablisme des carbohydrates est proposée.
Zusammenfassung
Neun Sandratten nahmen unter einer sehr fettreichen Diät an Gewicht zu, entwickelten eine endogene Hyperinsulinämie und eine Resistenz gegenüber exogen zugeführtem Insulin, ohne daß es zu einer weiteren Verschlechterung der Glucosetoleranz kam. Die Hyperinsulinämie, wie sie 4 Std nach Glucosegaben bei einem Teil der Tiere unter beiden Diäten festgestellt wurde, könnte Ausdruck einer chronischen Belastung der Inseln bei diesen Tieren mit verteilter Nahrungsaufnahme sein. Fünf Tiere überlebten das Setzen der Läsionen. Die Ergebnisse stimmten mit früher erhobenen Befunden überein, daß Läsionen im Bereich der eminentia mediana posterior des periventrikulären Systems die Glucosetoleranz verbessern, wobei sie in der vorliegenden Untersuchung die Empfindlichkeit gegenüber exogen zugeführtem Insulin verstärkten. Für den Mechanismus dieser Effekte auf den KH'Stoffwechsel wird eine Erklärungsmöglichkeit vorgeschlagen.
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Brodoff, B.N., Kagan, A., Slotnik, B. et al. The effect of hypothalamic lesion in the sand rat maintained on a high fat diet. Diabetologia 7, 59–67 (1971). https://doi.org/10.1007/BF00443882
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DOI: https://doi.org/10.1007/BF00443882