Summary
Median eminence lesions, in the area of the arcuate nucleus, appear to decrease, one hour post oral glucose, blood glucose levels in hyperglycemic rats, independent of changes in weight.
Résumé
Des lésions placées au niveau du nucléus arcuatus semblent diminuer les taux de glucose sanguin observés une heure après une surcharge par voie orale chez les animaux par ailleurs hyperglycémiques.
Zusammenfassung
Laesionen in der Gegend des Nucleus Arcuatus scheinen die nach einer Stunde nach Glucoseper os erhaltenen Blutzuckerwerte bei hyperglykämischen Sandratten zu vermindern.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Abrams, R.L., Parker, M.L., Blanco, S., Reichlin, S., Daughaday, W.H.: Hypothalamic regulation of growth hormone secretion. Endocrinology70, 605 (1966).
Bergman, H.C., Drury, D.R.: Effect of feeding and fasting on sugar utilization of eviscerated rabbits. Proc. Soc. exp. Biol.37, 414–417 (1937).
Bernard, C.: Leçons sur le diabète et la glycogénèse animale, p. 70. Paris, 1877.
Brodoff, B.N., Zeballos, G., Dorn, J.: Amelioration of the diabetic glucose tolerance of the sand rat after hypothalamic injury. Metabolism,6, 744 (1967).
— — —: A possible role for the central nervous system in sand rat diabetes. Excerpta medica international congress series No.172, proceedings of the VIth congress of the Int. Diabetes Federation Stockholm, Excpt. Med. Foundation, Amsterdam, p. 823 (1969).
Brodoff, B. N., Kagan, A., Hagedoorn, J., and Slotnik, B.: The effect of hypothalamic lesions in the sand rat maintained on a high fat diet.
Cahill, G.F.: Pathophysiology of diabetes. Med. Clin. N. Amer.49, 881–892 (1965).
Cotes, P.M., Reid, E., Young, F.G.: Nature (Lond.)164, 992 (1949).
Metz, R., Friedenberg, R.: Investigation of the Staub-Traugott effect. Diabetes18, Suppl.1, 327 (1969).
Greeley, P.O.: Proc. Soc. exp. Biol.32, 1070 (1935).
Hackel, D.B., Schmidt-Nielsen, K., Haines, H.B., Mikat, E.: Diabetes mellitus in the sand rat (Psammomys obesus). Lab. Invest.14, 200–207 (1965).
—, Mikat, E., Lebovitz, H.E., Schmidt-Nielsen, K.: Diabetes mellitus like disease in sand rats (Psammomys obesus). Diabetes (proceedings of the sixth congress of the International Diabetes Federation, J. Ostman, Excpt. Med. Foundation, Amsterdam, p.800, 1969.
—, Frohman, L.A., Mikat, E., Lebovitz, H.E., Schmidt-Nielsen, K., Kinney, T.D.: Effect of diet on the glucose tolerance and plasma insulin levels of the sand rat (Psammomys obesus) Diabetes15, 105–114 (1966).
— — — — — —: Review of current studies on effect of diet on the glucose tolerance of the sand rat (Psammomys obesus). Ann. N.Y. Acad. Sci.131, 459–463 (1966).
Hamman, Hirschman: Johns Hopk. Hosp.30, 306 (1919).
Houssay, B.A., Biasotti, A.: C.R. Soc. Biol.104, 407; 105,121, 124 (1930).
Ingle, D.J.: Experimental glycosuria in the rat. Recent Progr. Hormone Res.21, 229 (1948).
Katz, S., Krulich, L., McCann, S.M.: Effect of insulin-induced hypoglycemia on the concentration of GHRF in plasma and hypothalamus of the rat. Fed. Proc.25, 191 (1966).
Krulich, L., Dharwol, A.P.S., McCann, S.M.: Hypothalamic control of growth hormone (GH) secretion. Abstracts. Annual Meeting of the Endocrine Society21 (1965).
Like, A.A., Milki, E.: Diabetic syndrome in sand rats. IV. Morphologic changes in islet tissue. Diabetologia3, 143–166 (1967).
McCann, S.M., Porter, J.C.: Hypothalamic pituitary stimulating and inhibiting hormones. Physiol. Rev.49, 240–284 (1969).
Marshall, W.S., Barnett, R.J., Mayer, J.: Hypothalamic lesions in goldthioglucose injected mice. Proc. Soc. exp. Biol. (N.Y.)9, 240 (1955).
Mayer, J.: Physiol. Rev.33, 472 (1953).
Miki, E., Like, A.A., Steinke, J., Soeldner, J.S.: Diabetic syndrome in sand rats. II. Variability and association with diet. Diabetologia3, 135–139 (1967).
— —, Soeldner, J.S., Steinke, J., Cahill, G.F., Jr.: Acute ketotic-type diabetic syndrome in sand rats (Psammomys obesus) with special reference to the pancreas. Metabolism15, 749–760 (1966).
Neel, J.V.: Diabetes mellitus: a ‘thrifty’ genotype rendered detrimental by ‘progress’ ? Amer. J. Human. Genet.14, 353 (1962).
Reichlin, S.: Growth and the hypothalamus. Endocrinology67, 760 (1960).
Roth, J., Glick, S.M., Yalow, R.S., Berson, S.A.: Hypoglycemia: A potent stimulus to secretion of growth hormone. Science140, 987–988 (1963).
Schmidt-Meisen, K., Haines, H.B., Hackel, D.B.: Diabetes mellitus in the sand rat induced by standard diets. Science143, 689–690 (1964).
Soskin, S., Mirsky, I.A., Zimmerman, L.M., Heller, R. C.: Indispensability of the hypophysis to the Staub-Traugott phenomenon. Amer. J. Physiol.116, 148 (1936).
Straub, H.: Untersuchungen über den Zuckerstoffwechsel des Menschen. I. Mitteilung: Über das Verhalten des Blutzuckers nach peroraler Zufuhr kleiner Glukosemengen. Z. Min. Med.91, 44 (1921).
Sweeney,: Arch. Intern. Med.40, 818 (1927).
Szabo, A., Maier, J., Szabo, O., Camerini-Davalos, R.: Improved glucose disappearance following repeated glucose administration. Diabetes18, 232 (1969).
Traugott, K.: Über das Verhalten des Blutzuckerspiegels bei wiederholter und verschiedener Art enteraler Zuckerzufuhr und dessen Bedeutung für die Leberfunktion. Klin. Wschr.1, 892 (1922).
Unger, R.H., Eisentraut, A.M., Madison, L.L.: The effects of total starvation upon the levels of circulating glucagon and insulin in man. J. clin. Invest.42, 1031–1039 (1963).
Reichlin, S.: Neuroendocrinology. New Engl. J. Med. medicine269, 1182 (1963).
Coleman, D.L., Hummel, K.P.: The effects of hypothalamic lesions in genetically diabetic mice. Diabetologia6, 263–267 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brodoff, B.N., Zeballos, G. Further studies on the effect of hypothalamic lesions in the sand rat (Psammomys obesus). Diabetologia 6, 366–370 (1970). https://doi.org/10.1007/BF01212251
Issue Date:
DOI: https://doi.org/10.1007/BF01212251