Abstract
Fibrinogen half-life was determined in 3 healthy individuals and in 17 children with cyanotic congenital heart disease. Fibrinogen half-life was normal in the healthy individuals and shortened in 9 of the 17 patients. The simultaneously performed coagulation tests were often pathological but did not lead to a clear diagnosis of the haemostatic defect and did not correlate with the fibrinogen half-life. Significant correlations were found between fibrinogen half-life and red cell count (P<0.001), packed cell volume (P<0.001), mean corpuscular volume of the red cell (P<0.001), platelet count (P<0.01), aortic oxygen saturation (P<0.001), base excess (P<0.01), and maximal amplitude of the thrombelastography (P<0.001). The results indicate a definite relationship between the hypoxaemia and the frequently observed disturbance of haemostasis in cyanotic heart disease. The chronic hypoxaemia causes a partly compensated intravascular coagulation with increased fibrinogen metabolism.
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Supported by Land Nordrhein-Westfalen, Ministerium für Wissenschaft und Forschung
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Thies, W.R., Göbel, U. & Liersch, R. Fibrinogen half-life in children with cyanotic congenital heart disease. Eur J Pediatr 139, 43–47 (1982). https://doi.org/10.1007/BF00442078
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DOI: https://doi.org/10.1007/BF00442078