Abstract
An 8-year-old boy with an hepatic form of Wilson disease was treated with oral zinc sulphate as the primary and sole therapy. After 4 months, liver function had dramatically improved, and the parameters characterizing copper metabolism had also normalized.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- d-pen:
-
d-penicillamine
- IU:
-
international units
- SCp:
-
serum ceruloplasmin
- SD:
-
standard deviation
- SGGT:
-
serum gamma-glutamyltransferase
- SGOT:
-
serum glutamic-oxalic transaminase
- SGPT:
-
serum glutamic-pyruvic transaminase
References
Alexiou D, Hatzis T, Koutselinis A (1985) Traitement d'entretien de la maladie de Wilson par le zinc per os. Arch Fr Pediatr 42: 447–449
Brewer GJ, Hill GM, Prasad AS, Cossack ZT, Rabbani P (1983) Oral zinc therapy for Wilson's disease. Ann Intern Med 99:314–320
Brewer CJ, Hill GM, Dick RD, Nostrant TT, Sams JS, Wells JJ, Prasad AS (1987) Treatment of Wilson's disease with zinc: III. Prevention of reaccumulation of hepatic copper. J Lab Clin Med 109:526–531
Cossack ZT (1988) The efficacy of oral zinc therapy as an alternative to penicillamine for Wilson disease. N Engl J Med 318:322–323
Cossack ZT, Bouquet J (1986) The treatment of Wilson's disease in paediatrics: oral zinc therapy versus penicillamine. Acta Pharmacol Toxicol (Copenh) [Suppl 7] 59:514–517
Hoogenraad TU, Koevoet R, Kuyter Korver EGWM de (1979) Oral zinc sulphate as long-term treatment in Wilson's disease (Hepatolenticular degeneration). Eur Neurol 18:205–211
Hoogenraad TU, Van den Hamer CJA, Van Hattum J (1984) Effective treatment of Wilson's disease with oral zinc sulphate: two case reports. Br Med J 289:273–276
Marrella M, Milanino R (1986) Simple and reproducible method for acid extraction of copper and zinc from rat tissue for determination by flamic spectroscopy. At Spectrosc 7: 40–42
Sandstead HH (1987) Zinc-copper interaction provides a novel and apparently effective alternative therapy for Wilson's disease. J Lab Clin Med 109:521–522
Scheinberg IH, Sternielb I (1984) Wilson's disease. Major problems in internal medicine, vol XXIII. Saunders, Philadelphia, p 171
Van Caillie-Bertrand M, Degenhart HJ, Visser HKA, Siaasappel M, Bouquet J (1985) Oral zinc sulphate for Wilson's disease. Arch Dis Child 60:656–659
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Milanino, R., Marrella, M., Moretti, U. et al. Oral zinc sulphate as primary therapeutic intervention in a child with Wilson disease. Eur J Pediatr 148, 654–655 (1989). https://doi.org/10.1007/BF00441526
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00441526