Abstract
Cocaine, pemoline and amphetamine have been tested on mice trained to swim toward the light (L Procedure) or toward the dark (D Procedure) in a Y water-maze, in pre- and post-trial experiments.
In the pre-trial experiments no differences between controls and drugged animals appeared under the L Procedure (ceiling effect), while in the D Procedure all drugs induced a clear facilitation; however, while a state dependent effect was evident for cocaine no state dependency appeared following pemoline and amphetamine administration.
In the post-trial experiments (D Procedure), cocaine did not affect retention, while the other two drugs induced clear facilitating effects on the consolidation processes. No effect on the performance of trained animals in either procedures appeared following pemoline administration.
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Castellano, C. Cocaine, pemoline and amphetamine on learning and retention of a discrimination test in mice. Psychopharmacologia 36, 67–76 (1974). https://doi.org/10.1007/BF00441383
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DOI: https://doi.org/10.1007/BF00441383