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Structure activity relations of some indolealkylamines in comparison to phenethylamines on motor activity and acquisition of avoidance behavior

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Abstract

The structure-activity relationships (SAR) of various known hallucinogenic and nonhallucinogenic indolealkylamine and phenethylamine derivatives were compared on two different behaviors: mouse locomotor activity and acquisition of one-way avoidance behavior in the rat. Certain parallels were observed between the two classes of compounds. α-Methyl substituted derivatives of the indoles and phenethylamines increased dramatically psychomotor stimulant effects. Acquisition of one-way avoidance behavior was reduced by the more potent hallucinogens and psychomotor stimulants of both classes. Pargyline pretreatment enhanced the psychomotor stimulant effects of all of the compounds tested except 5-hydroxy-tryptamine (5-HT), d-amphetamine, mescaline and lysergic acid diethylamide (LSD-25).

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Authors and Affiliations

  1. Michigan Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michingan, Ann Arbor

    Michael R. Vasko, Michael P. Lutz & Edward F. Domino

  2. Michigan and Lafayette Clinic, Detroit, Michigan

    Michael R. Vasko, Michael P. Lutz & Edward F. Domino

Authors
  1. Michael R. Vasko
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  2. Michael P. Lutz
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  3. Edward F. Domino
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Additional information

Supported in part by USPHS grant MH-11846.

Predoctoral fellow in the Department of Pharmacology, University of Michigan.

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Vasko, M.R., Lutz, M.P. & Domino, E.F. Structure activity relations of some indolealkylamines in comparison to phenethylamines on motor activity and acquisition of avoidance behavior. Psychopharmacologia 36, 49–58 (1974). https://doi.org/10.1007/BF00441381

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  • DOI: https://doi.org/10.1007/BF00441381

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