Abstract
In order to study the relationship between dopamine (DA) and serotonin (5-HT) mechanisms in the caudate nucleus of cats, a behavioural analysis has been made of effects brought about by simultaneously or successively administered injections of DA, 5-HT, carbachol and some related compounds into the DA-sensitive caput nuclei caudati rostromedialis (CRM-area) and the 5-HT-sensitive caput nuclei caudati anteroventralis (CAV-area) in cats. The data reported here show that inhibition of the 5-HT activity in the CAV-area abolishes the effects elicited by activation of the DA mechanism in the CRM-area, and that inhibition of the DA mechanism in the CRM-area does not influence the effects elicited by inhibition of the 5-HT activity in the CAV-area. Furthermore, this study shows that inhibition of the cholinergic mechanism in the CAV-area abolishes the effects elicited by the activation of the DA mechanism in the CRM-area.
Finally, the experiments reveal that inhibition of the 5-HT mechanism in the CAV-area abolishes the effects elicited by activation of the cholinergic mechanism in the CAV-area, whereas inhibition of the cholinergic mechanism does not affect the effects elicited by activation of the 5-HT mechanism in this area.
A model by which these neurotransmitter systems might operate is proposed.
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Cools, A.R. The transsynaptic relationship between dopamine and serotonin in the caudate nucleus of cats. Psychopharmacologia 36, 17–28 (1974). https://doi.org/10.1007/BF00441378
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DOI: https://doi.org/10.1007/BF00441378