Abstract
The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalanine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxytryptophan, l-Dopa or α-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia.
Brain 5-HT and cAMP are probably involved in tremorine tolerance, whereas neither noradrenaline nor dopamine is involved in the phenomenon.
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Naik, S.R., Amladi, S.R. & Sheth, U.K. Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice. Psychopharmacology 52, 213–216 (1977). https://doi.org/10.1007/BF00439113
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DOI: https://doi.org/10.1007/BF00439113