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Rat ethanol intake: Suppression by intracranial surgery and facilitation by intracranial stimulation

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Abstract

Implantation of stimulating electrodes into the rat lateral hypothalamus suppressed subsequent home-cage ethanol intake. Lateral hypothalamic stimulation overcame this influence, returning animals to the levels of unimplanted, unstimulated control animals. The effects of surgery were temporary; the implanted control animals reached the intake levels of the stimulated and unimplanted control animals after 60 days of ethanol exposure. Control animals that were given pentobarbital or ether anesthesia without surgical insult drank as much as unimplanted controls.

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Authors and Affiliations

  1. Center for Research on Drug Dependence, Department of Psychology, Sir George Williams University, Montreal, Canada

    Roy A. Wise & Linda James

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  1. Roy A. Wise
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  2. Linda James
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Additional information

Supported in part by Grant No. R01 MH21850-01 from the United States Public Health. Service and by a grant from the Licensed Beverage Industries.

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Wise, R.A., James, L. Rat ethanol intake: Suppression by intracranial surgery and facilitation by intracranial stimulation. Psychopharmacologia 37, 179–184 (1974). https://doi.org/10.1007/BF00437424

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  • DOI: https://doi.org/10.1007/BF00437424

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