Abstract
Questionnaires, motor-skill and cognitive tests were given to 3 groups of 12 healthy young men after administration of either 0,10 or 20 mg of medazepam (Nobrium). Tests were given both before and after experimental intoxication with 1 ml/kg bodyweight of diluted ethanol. On most tests medazepam did not interact with alcohol: no synergistic or antagonistic drug reaction was observed. A greater subjective fatigue rating by the drug groups was not confirmed by objective measures. The use of psychoactive drugs with ambulant patients is discussed and it is concluded that medazepam medication has no detrimental effect on driving ability.
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Landauer, A.A., Pocock, D.A. & Prott, F.W. The effect of medazepam and alcohol on cognitive and motor skills used in car driving. Psychopharmacologia 37, 159–168 (1974). https://doi.org/10.1007/BF00437422
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DOI: https://doi.org/10.1007/BF00437422