Abstract
The prevalence of oral colonization with C. albicans was studied in 40 children with acute lymphoblastic leukaemia (ALL) and 40 matched normal children. Colonization was more common in the ALL group (25% colonized) than the normal group (7.5% colonized). Total saliva IgA levels were lower in the ALL group, but low levels did not correlate with oral colonization. The three normal children with oral colonization all had anti-C. albicans IgA in their saliva, as had seven of the ten colonized ALL patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Arendorf, T. M. & D. M. Walker, 1979. Oral candidal populations in health and disease. Br. Dental J. 147: 267–272.
Clayton, Y. M. & W. C. Noble, 1966. Observations on the epidemiology of Candida albicans. J. clin. Pathol. 19: 76–78.
Harding, S. A. & W. G. Merz, 1975. Evaluation of antibody coating of yeasts in urine as an indicator of the site of urinary tract infection. J. clin. Microbiol. 2: 222–225.
Hughes, W. T., 1971. Fatal infections in childhood leukemia. Am. J. Dis. Child. 122: 283–287.
Hughes, W. T., 1982. Systemic candidiasis: a study of 109 fatal cases. Paediat. Infect. Dis. 1: 11–18.
Johnston, D. A. & G. P. Bodey, 1970. Semiquantitative oropharyngeal culture technique. Appl. Microbiol. 20: 218–223.
Marks, M. I., S. Marks & M. Brazeau, 1975. Yeast colonization in hospitalized and nonhospitalized children. J. Pediatr. 87: 524–527.
Martin, M. V. & G. R. Wilkinson, 1983. The oral yeast flora of 10-year-old schoolchildren. Sabouraudia 21: 129–135.
Taschdjian, C. L., J. J. Burchall & P. J. Kozinn, 1960. Rapid identification of Candida albicans by filamentation on serum and serum substitutes. Am. J. Dis. Child. 99: 212–215.
Tomasi, T. B. & H. M. Grey, 1972. Structure and function of immunoglobulin A. In: P. Kallos, B. H. Waksman & A. de Weck (eds), Progress in Allergy 16. Karger, Basel: 81–213.
Vudhichamnong, K., D. M. Walker & H. C. Ryley, 1982. The effect of secretory immunoglobulin A on the in vitro adherence of the yeast Candida albicans to human oral epithelial cells. Arch. oral Biol. 27: 617–621.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gentle, T.A., Warnock, D.W. & Eden, O.B. Prevalence of oral colonization with Candida albicans and anti-C. albicans IgA in the saliva of normal children and children with acute lymphoblastic leukaemia. Mycopathologia 87, 111–114 (1984). https://doi.org/10.1007/BF00436638
Issue Date:
DOI: https://doi.org/10.1007/BF00436638