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Proprietes antibacteriennes et genotoxiques de 33 mycotoxines

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Abstract

Most of the 33 fungal metabolites tested provoke:

  1. 1.

    Bacterial growth inhibition of Bacillus thuringiensis similar to lethal effect of antibiotics.

  2. 2.

    Positive response in the ‘Rec’ assay using strains of Bacillus subtilis; this fact shows that these toxins are DNA modifying agents.

  3. 3.

    Enlargement of cell volume in the first bacteria species; this cell-abnormality induction resembles those obtained with mitomycin C.

Correlation between elongation of cells (filamentation) and in vivo carcinogenicity of mycotoxins is discussed.

The filamentation should be an expression of a perturbated DNA replication (S.O.S.-error prone repair) as the consequence of DNA damages induced by genotoxic agents (i.e. carcinogens).

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Authors and Affiliations

  1. Laboratoire de Génétique Microbienne, U.E.R. des Sciences de l'Alimentation et de la Nutrition, Université de Caen, 14032, Caen Cedex, France

    P. Boutibonnes, Y. Auffray, C. Malherbe, W. Kogbo & C. Marais

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  1. P. Boutibonnes
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  2. Y. Auffray
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  3. C. Malherbe
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  4. W. Kogbo
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  5. C. Marais
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Boutibonnes, P., Auffray, Y., Malherbe, C. et al. Proprietes antibacteriennes et genotoxiques de 33 mycotoxines. Mycopathologia 87, 43–49 (1984). https://doi.org/10.1007/BF00436626

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