Summary
Thirty-four femoral necks from human cadavers were measured by techniques assessing bone density and bone mineral density, and by the Singh index. These methods are based on photon interaction with biological components and can be applied noninvasively for clinical evaluation of changes in skeletal status. Trabecular bone volume, mineralized bone volume, and relative osteoid volume were evaluated histomorphometrically using undecalcified histologic sections obtained from the same samples. The trabecular and mineralized bone volumes showed significant correlations with the bone density and mineral density. These results enhance the validity of recently developed photoninteraction techniques for evaluating bone properties.
Zusammenfassung
Es wird über die Möglichkeit von nicht invasiven Untersuchungstechniken zur Bestimmung der Knochen- and Knochenmineraldichte berichtet. Diese Methoden basieren auf der Photonen-Interaktion mit biologischen Komponenten und kön-nnen eingesetzt werden, um Veränderungen des knöchernen Skelettes zu bewerten. Zur Untersuchung dienten 34 menschliche Leichenhüftköpfe. Die Ergebnisse wurden verglichen mit histomorphometrisch an unentkalkten Knochenschnitten der gleichen Proben ermittelten trabeculären Knochenvolumen, mineralisierten Knochenvolumen and relatives Osteoidvolumen. Es zeigte sich eine signifikante Korrelation zwischen trabeculärem and mineralisiertem Knochenvolumen mit der Knochen- und Mineraldichte. Diese Befunde erhöhen den Wert der kürz lich entwickelten Techniken der Photonen-Interaktion zur Bewertung von Knocheneigenschaften.
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References
Barnett E, Nordin BEC (1961) The radiological diagnosis of osteoporosis. Clin Radiol 11:166–174
Cameron JR, Mazess RB, Sorenson JA (1968) Precision and accuracy of bone mineral determination by direct photon absorptiometry. Invest Radiol 3:141–150
Christiansen C, Rodbro P, Jensen H (1975) Bone mineral content in the forearm measured by photon absorptiometry — principles and reliability. Scand J Clin Lab Invest 35:323–330
Dequeker J (1975) Bone and aging. Ann Rheum Dis 34:100–115
Frost HM, Griffith DL, Jee WSS, Kimmel DB, McCardlis RP, Teitelbaum SL (1981) Histomorphometric changes in trabecular bone of renal failure patients treated with Calcifediol. Metab Bone Dis Rel Res 2:285–295
Hazan G, Leichter I, Loewinger E, Weinreb A, Robin GC (1977) The early detection of osteoporosis by Compton gamma ray spectroscopy. Phys Med BioL 22:1073–1084
Kranendonk DH, Jurist JM, Lee HG (1972) Femoral trabecular patterns and bone mineral content. J Bone Joint Surg [Am] 54:1472–1478
Leichter I, Weinreb A, Hazan G (1980) On the effective attenuation coefficient of the soft tissue in the presence of Compton scattering from bone: experiments on models. Phys Med Biol 25:711–717
Leichter I, Hazan G, Weinreb A, Loewinger E, Robin GC, Menczel J, Makin M (1981) The effect of age and sex on bone density, bone mineral content and cortical index. Clin Orthop Rel Res 156:232–239
Leichter I, Margulies JY, Weinreb A, Mizrahi J, Robin GC, Conforti B, Makin M, Rloch B (1982) The relationship between bone density, mineral content and mechanical strength in femoral neck. Clin Orthop Rel Res 163:272–281
Robin GC, Steinberg R, Leichter I, Menczel J, Makin M (1982) A comparison of non-invasive methods in the diagnosis of osteoporosis. In: Menczel J, Robin GC, Makin M, Steinberg R (eds) Osteoporosis. John Wiley and Sons, New York, pp 71–79
Singh M, Magrath AR, Maim PS (1970) Changes in trabecular pattern on the upper end of the femur as an index of osteoporosis. J Bone Joint Surg [Am] 52:457–467
Smith DM, Khairi MRA, Johnston CC jr (1975) The loss of bone mineral with aging and its relationship to risk of fracture. J Clin Invest 56:311–318
Sorenson JA, Cameron JR (1967) A reliable in vivo measurement of bone mineral content. J Bone Joint Surg [Am] 49:481–497
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Margulies, J.Y., Leichter, I., Robin, G.C. et al. A correlative assessment of photon interaction and histomorphometric measurements of bone density. Arch. Orth. Traum. Surg. 105, 239–242 (1986). https://doi.org/10.1007/BF00435489
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DOI: https://doi.org/10.1007/BF00435489