Abstract
The effects of tryptophol (TOL) on brain 5-hydroxytryptamine (5-HT) metabolism were studied. After TOL injection (200 mg/kg IP), brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels were increased, 5-HT synthesis rate was decreased, and monoamine oxidase (MAO) activity remained unchanged. Pretreatment of mice with p-chlorophenylalanine (PCPA), a potent inhibitor of 5-HT synthesis, did not affect the anticonvulsant action of TOL. These results suggest that alteration of 5-HT metabolism after TOL injection is not directly related to the anticonvulsant action of TOL.
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Chadwick D, Gorrod JW, Jenner P, Marsden CD, Reynolds EH (1978) Functional changes in central 5-hydroxytryptamine metabolism in the mouse induced by anticonvulsant drugs. Br J Pharmacol 62:115–124
Fukumori R, Minegishi A, Satoh T, Kitagawa H, Yanaura S. (1979) Effect of disulfiram on turnover of 5-hydroxytryptamine in rat brain. Life Sci 25:123–130
Jenner P, Chadwick D, Reynolds EH, Marsden CD (1975) Altered 5-HT metabolism with clonazepam and diphenylhydantoin. J Pharm Pharmacol 27:707–710
Kilian M, Frey HH (1973) Central monoamines and convulsive thresholds in mice and rats. Neuropharmacology 12:681–692
Koe BK, Weissman A (1966) p-Chlorophenylalanine: A specific depletor of brain serotonin. J Pharmacol Exp Ther 154:499–516
Lidbrink P, Corrodi H, Fuxe K (1974) Benzodiazepines and barbiturates: Turnover changes in central 5-hydroxytryptamine pathways. Eur J Pharmacol 26:35–40
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
Minegishi A, Fukumori R, Satoh T, Kitagawa H, Yanaura S (1979a) Changes in serotonin turnover and the brain sensitivity to barbiturates by disulfiram treatment in rats. Res Commun Chem Pathol Pharmacol 24:273–287
Minegishi A, Satoh T, Fukumori R, Kitagawa H, Yanaura S (1979b) Susceptibility of brain aldehyde-metabolizing enzymes to pargyline, disulfiram and diethylmaleate in vivo in rats. Life Sci 24:1131–1136
Perez-Cruet J, Tagliamonte A, Tagliamonte P, Gessa GL (1971) Stimulation of serotonin synthesis by lithium. J Pharmacol Exp Ther 178:325–330
Ris MM, Deitrich RA, von Wartburg JP (1975) Inhibition of aldehyde reductase isoenzymes in human and rat brain. Biochem Pharmacol 24:1865–1869
Satoh T, Fukumori R, Nakagawa I, Minegishi A, Kitagawa H, Yanaura S (1979a) Effect of tryptophol on pentylenetetrazol-and picrotoxin-induced convulsion in mice. Life Sci 24:2031–2036
Satoh T, Fukumori R, Nakagawa I, Minegishi A, Kitagawa H, Yanaura S (1979b) The effects of pyrazole and chlorpromazine on the anticonvulsant action of tryptophol in mice. Res Commun Psychol Psychiatr Behav 4:285–298
Satoh T, Fukumori R, Minegishi A, Kitagawa H, Yanaura S (1979c) Induction of NADH-dependent aldehyde reductase by successive administration of barbiturates in rat brain. Res Commun Chem Pathol Pharmacol 23:279–311
Snyder SH, Axelrod J, Zweig M (1965) A sensitive and specific fluorescence assay for tissue serotonin. Biochem Pharmacol 14:831–835
Tozer TN, Neff NH, Brodie BB (1966) Application of steady-state kinetics to the synthesis rate and turnover rate and turnover time of serotonin in the brain of normal and reserpine-treated rats. J Pharmacol Exp Ther 153:177–182
Ungar FU, Alivisatos SGA (1976) Subsynaptosomal distribution, inhibition, and characterization of the binding of [14C]-5-OH-indole-3-acetaldehyde to brain preparation. Res Commun Chem Pathol Pharmacol 13:449–464
Winer BJ (1971) Statistical principles in experimental design. McGraw Hill, New York
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Fukumori, R., Minegishi, A., Satoh, T. et al. Tryptophol-induced change in brain 5-hydroxytryptamine metabolism. Psychopharmacology 69, 243–246 (1980). https://doi.org/10.1007/BF00433089
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DOI: https://doi.org/10.1007/BF00433089