Summary
Vinylpyrrolidone-vinylacetate (VP-VA) the major component of many commercial hair-sprays was injected endotracheally in female Wistar rats. The material is stored in large macrophages which often fill the alveolar spaces completely. There is no inflammation associated with the process. The alveoli, however, contain a large amount myelin structures some lamellar, mostly however in a lattice-like form. It is suggested that this material is associated with the surfactant. Some of the VP-VA is obviously eliminated from the lung via interstitial macrophages and the lymphatics, most of it, however, over the mucociliary pathway.
Following subcutaneous injection of VP-VA most of the material is stored in the spleen, which considerably enlarges, and some in other organs.
The excretion is via the urinary system.
Even 12 months following the last endotracheal or subcutaneous injection there is no evidence of tumor or systemic disease.
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Blessing, M.H. Storage of vinylpyrrolidone-vinylacetate (VP-VA) in rats following endotracheal and subcutaneous injection. Virchows Arch. A Path. Anat. and Histol. 362, 115–128 (1974). https://doi.org/10.1007/BF00432390
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DOI: https://doi.org/10.1007/BF00432390