Abstract
Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate the antihistaminic tripelennamine (5 mg/kg) from saline. When 0.63–7.5 mg/kg doses of tripelennamine were administered in generalization test sessions, the percentage of responses directed to the tripelennamine-appropriate key varied directly with dose. At certain doses, the discriminative stimulus properties of the antihistaminics, diphenhydramine and pyrilamine, clearly generalized to tripelennamine, whereas intermediate generalization was evident with the antihistaminics, chlorpheniramine and promethazine. Chlorpromazine, cimetidine, d-amphetamine, diazepam, morphine, pentazocine, phenobarbital, and sodium valproate failed to produce tripelennamine-like patterns of responding.
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References
Douglas WW (1980) Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. In: Gilman G, Goodman LS, Gilman A (eds), The pharmacological basis of therapeutics. Macmillan, New York, pp 609–646
Grossett D, Wallace S, Picker M, Poling A (1984a) Effects of tripelennamine and pentazocine alone and in combination on fixed-ratio responding of rats. Bull Psychon Soc 22:232–234
Grossett D, Wallace S, Picker M, Poling A (1984b) Tripelennamine and pentazocine alone and in combination: Effects on the interresponse-time-greater-than-t responding of rats. Pharmacol Biochem Behav 20:697–700
Overton DA (1978) Discriminable effects of antihistamine drugs. Arch Int Pharmacodyn Ther 232:221–226
Overton DA (1982) Comparison of the degree of discriminability of various drugs using the t-maze drug discrimination paradigm. Psychopharmacology 76:385–395
Poling A, Kesselring J, Sewell R, Cleary J (1983) Lethality of pentazocine and tripelennamine combinations in mice housed individually and in groups. Pharmacol Biochem Behav 18:103–105
Shannon HE, Su T-P (1982) Effects of the combination of tripelenamine and pentazocine at the behavioral and molecular levels. Pharmacol Biochem Behav 17:789–795
Showalter CV (1980) T's and blues: Abuse of pentazocine and tripelennamine. JAMA 224:1224–1225
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Karas, C.A., Picker, M. & Poling, A. Discriminative stimulus properties of tripelennamine in the pigeon. Psychopharmacology 86, 356–358 (1985). https://doi.org/10.1007/BF00432228
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DOI: https://doi.org/10.1007/BF00432228