Abstract
Dopamine (DA) sensitivity, assessed through maximal growth hormone (GH) response to stimulation by apomorphine (APO) (0.18–0.24 mg iv) was studied in 16 chronic alcoholics newly admitted after a period of heavy alcohol intake. Repeated hormonal tests were thereafter performed during a 2-month period under strictly controlled conditions to avoid relapse into alcohol consumption. Eight healthy volunteers with alcohol consumption slightly less than that of the general population were used as controls. It was found that DA sensitivity in the early abstinence phase was higher than later in the 2-month recovery period but not significantly different from control values. The relatively higher DA sensitivity in the early abstinence phase might be responsible for a lower threshold for psychotic symptoms and neuroleptic-induced extrapyramidal side effects. The results of this study give further evidence of a prolonged recovery phase after heavy alcohol intake.
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Alling C, Balldin J, Bokström K, Gottfries CG, Karlsson I, Långström G (1982) Studies on duration of a late recovery period after chronic abuse of alcohol. A cross-sectional study of biochemical and psychiatric indicators. Acta Psychiatr Scand 66:384–397
Andén NE, Rubenson A, Fuxe K, Hökfelt T (1967) Evidence for dopamine receptor stimulation by apomorphine. J Pharm Pharmacol 19:627–629
Annuziato L, Amoroso S, Di Renzo G, Argenzio F, Aurilio C, Grella A, Quattrone A (1983) Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome. Life Sci 33:2651–2655
Asberg M, Perris C, Schalling D, Sedvall G (1978) The CPRS-Development and applications of a psychiatric rating scale. Acta Psychiatr Scand Suppl 271
Balldin J, Granérus AK, Lindstedt G, Modigh K, Wålinder J (1982) Neuroendocrine evidence for increased responsiveness of dopamine receptors in humans following electroconvulsive therapy. Psychopharmacology 76:371–376
Barbaccia ML, Reggiani A, Spano PF, Trabucchi M (1980) Ethanol effects on dopaminergic function: Modulation by the endogenous opioid system. Pharmacol Biochem Behav 13:303–306
Begleiter H, Porjesz B (1979) Persistence of a “subacute withdrawal syndrome” following chronic ethanol intake. Drug and Alcohol Dependence 4:353–357
Borg S, Kvande H, Sedvall G (1981) Central norepinephrine metabolism during alcohol intoxication in addicts and healthy volunteers. Science 213:1135–1137
Carlén PL, Lee MA, Jacob M, Livshits O (1981) Parkinsonism provoked by alcoholism. Ann Neurol 9:84–86
Checkley SA (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychol Med 10:35–53
Cook TM, Komiskey HL, Hayton WL (1980) The influence of ethanol withdrawal on the binding site of 3H-dopamine. Proc West Pharmacol Soc 23:157–158
Engel J, Liljeqvist S (1976) The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology 49:253–257
Fornazzari L, Carlen PL (1982) Transient choreiform dyskinesias during alcohol withdrawal. Can J Neurol Sci 9:89–90
Hollander M, Wolfe DA (1973) Non parametric statistical methods. John Wiley & Sons, New York London Sydney Toronto
Hunt WA, Dalton TK (1981) Neurotransmitter-receptor binding in various brain regions in ethanol-dependent rats. Pharmacol Biochem Behav 14:733–739
Laakman G, Treusch J, Eichmeier A, Schmauss M, Treusch U, Wahlster U (1982) Inhibitory effect of phentolamine on diazepam-induced growth hormone secretion and lack of effect of diazepam on prolactin secretion in man. Psychoneuroendocrinology 7:135–139
Lal S, De la Vega CE, Sourkes TL, Friesen HG (1972) Effect of apomorphine on human-growth-hormone secretion. Lancet ii:661
Lal S, De la Vega CE, Sourkes TL, Friesen HG (1973) Effect of apomorphine on growth hormone, prolactin, luteinizing hormone and follicle-stimulating hormone levels in human serum. J Clin Endocrinol Metab 37:719–724
Lal S, Martin JB (1980) Neuroanatomy and neuropharmacological regulation of neuroendocrine function. In: van Praag HM, Lader MH, Rafaelsen OJ, Sachar EJ (eds) Handbook of biological psychiatry. Part III. Brain mechanisms and abnormal behaviour — genetics and neuroendocrinology. Marcel Dekker, New York Basel, pp 101–167
Lal S (1981) Clinical studies with apomorphine. In: Corsini GU, Gessa GL (eds) Apomorphine and other dopaminomimetics. Clinical pharmacology, vol 2. Raven Press, New York, pp 1–11
Lal S, Oravec M, Aronoff A, Kiely ME, Guyda H, Solomon S, Nair NPV (1982) Hypothalamic-pituitary dopaminergic function in hepatic failure in man. J Neural Transm 53:7–21
Leurell CB (1972) Electroimmunoassay. Scand J Clin Lab Invest 29, suppl 124:21–37
Lehmann EL (1975) Non-parametric statistical methods based on ranks. McGraw Hill, San Francisco
Liljeqvist S, Engel J, Yoshida K (1981) Behavioral and biochemical changes in rats exposed to chronic ethanol treatment. Soc Neuroscience 7:312. Abstract 104.8
Lutz EG (1976) Neuroleptic-induced akathisia and dystonia triggered by alcohol. JAMA 236:2422–2423
Muller P, Britton RS, Seeman P (1980) The effects of long-term ethanol on brain receptors for dopamine, acetylcholine, serotonin and noradrenaline. Eur J Pharmacol 65:31–37
Rabin RA, Wolfe BB, Dibner MD, Zahniser NR, Melchior C, Molinoff PB (1980) Effects of ethanol administration and withdrawal on neurotransmitter receptor systems in C57 mice. J Pharmacol Exp Ther 213:491–496
Reggiani A, Barbaccia ML, Spano PF, Trabucchi M (1980) Dopamine metabolism and receptor function after acute and chronic ehanol. J Neurochem 35:34–37
Rose RM, Jenkins CD, Hurst M, Livingston L, Hall RP (1982) Endocrine activity in air traffic controllers at work. I. Characterization of cortisol and growth hormone levels during the day. Psychoneuroendocrinology 7:101–111
Rotrosen J, Angrist B, Gershon S, Paquin J, Branchey L, Olehansky M, Halpern F, Sachar EJ (1979) Neuroendocrine effects of apomorphine: Characterization of resonse patterns and application to schizophrenia research. Br J Psychiatry 135:444–456
Sylvälahti EKG, Kanto JH (1975) Serum growth hormone, serum immunoreactive insulin and blood glucose response to oral and intravenous diazepam in man. Int J Pharmacol 12:74–82
Tabakoff B, Melchior C, Urwyler S, Hoffman PL (1980) Alterations in neurotransmitter function during the development of ethanol tolerance and dependence. Acta Psychiatr Scand 286:153–160
The Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology (1974) Recommended methods for the determination of four enzymes in blood. Scand J Clin Lab Invest 33:291–306
The Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology (1976) Recommended methods for the determination of γ-glutamyltransferase in blood. Scand J Clin Lab Invest 36:119–125
Wiberg A, Gottfries CG, Oreland L (1977) Low platelet monoamine oxidase activity in human alcoholics. Med Biol 55:181–186
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Balldin, J., Alling, C., Gottfries, C.G. et al. Changes in dopamine receptor sensitivity in humans after heavy alcohol intake. Psychopharmacology 86, 142–146 (1985). https://doi.org/10.1007/BF00431699
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DOI: https://doi.org/10.1007/BF00431699