Abstract
Using in rats a Conditioned Taste Aversion (CTA) procedure, chlorpromazine was shown to possess significant US properties at the highest dose tested (8 mg/kg IP repeated four times). In contrast, haloperidol failed to exert a similar effect at a dosage (1.6 mg/kg IPx4) at least twice as high, in terms of pharmacological activity, as the effective chlorpromazine dosage. These data suggest that the induction of neuroleptic extrapyramidal side effects and the antidopaminergic properties shared by the two drugs may not be responsible for the aversive effect of chlorpromazine. However, it cannot be excluded than haloperidol produces an aversion which is antagonized by some action of the drug not shared by chlorpromazine.
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The work reported in this paper was carried out with the expert technical assistance of Ms. Angela Valanzano. The author also wishes to acknowledge the help given by Dr. G. Bignami in the preparation of the manuscript
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Giardini, V. Conditioned taste aversion to chlorpromazine, but not to haloperidol. Psychopharmacology 86, 81–83 (1985). https://doi.org/10.1007/BF00431688
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DOI: https://doi.org/10.1007/BF00431688