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Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion

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Abstract

The effect of IV physostigmine administration on the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in normal subjects was determined. After an adjustment for differing CSF concentrations of probenecid, physostigmine was found to elevate CSF HVA and DOPAC concentrations. The authors discuss these changes in CSF HVA and DOPAC and their possible relationship to the ability of physostigmine to decrease the symptoms of some patients with tardive dyskinesia.

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Authors and Affiliations

  1. Psychiatry Service, VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA

    Kenneth L. Davis (Chief), Kym F. Faull, Leo E. Hollister, Jack D. Barchas & Philip A. Berger

  2. Mount Sinai School of Medicine of the City University of New York, CA, USA

    Kenneth L. Davis (Chief), Kym F. Faull, Leo E. Hollister, Jack D. Barchas & Philip A. Berger

  3. Palo Alto Veterans Administration Medical Center and Stanford University, CA, USA

    Kenneth L. Davis (Chief), Kym F. Faull, Leo E. Hollister, Jack D. Barchas & Philip A. Berger

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  1. Kenneth L. Davis
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  2. Kym F. Faull
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  3. Leo E. Hollister
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  4. Jack D. Barchas
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  5. Philip A. Berger
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Davis, K.L., Faull, K.F., Hollister, L.E. et al. Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion. Psychopharmacology 72, 155–160 (1981). https://doi.org/10.1007/BF00431649

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  • DOI: https://doi.org/10.1007/BF00431649

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