Summary
Temporary chronic administration of Beta-amino-propionitrile (B.A.P.N.) produced morphological and biochemical changes of the aortic wall of rat as well as abnormalities of the plasma lipid levels.
A hyperlipidic diet resulted in the blood plasma lipid abnormalities as B.A.P.N. intoxication.
Nine weeks of B.A.P.N. followed by 42 weeks of a hyperlipidic diet increased the aortic cholesterol level and induced an atheroma.
The diet alone produced only an endothelial lipid overload.
The structure of arterial wall played the decisive role in atherogenesis.
Similar content being viewed by others
References
Bouissou, H., Julian, M., Pieraggi, M.Th.: Approches de l'athérogénèse par le lathyrisme expérimental. Paroi Artérielle/Arterial Wall 1, 7–27 (1973)
I bis. Bouissou, H., Julian, M., Pieraggi, M.Th.: Aortic lathyrism and atheroma in the rat by prolonged hyperlipidic diet. Gerontology 24, 250–266 (1978)
Camejo, G., Lopez, A.: The very low density lipoproteins of cholesterol fed rabbits: A study of their structure and in vitro changes in plasma. Atherosclerosis 19, 139–152 (1974)
Carlson, K.: Ultracentrifugation of human lipoproteins. Adv. Exp. Med. Biol. 38, 273–276 (1973)
Davis, B.J.: Disc Electrophoresis II. Method and application to human serum proteins. Ann. N.Y. Acad. Sci. 121, 404–427 (1964)
Feliste, R., Dousset, N., Douste-Blazy, L.: Séparation des lipoprotéines plasmatiques de l'homme par l'électrophorèse en gel mixte de polyacrylamide. Clin. Chim. Acta 47, 329–333 (1973)
Hashimoto, S., Dayton, S., Alfin Slater, R.B.: Esterification of cholesterol by homogenates of atherosclerotic and normal aortas. Life Science 12, 1 (1973)
Hatch, F.T., Lees, R.S.: Practical methods for plasma lipoproteins analysis. Adv. Lipid Res. 6, 1–68 (1968)
Havel, R.J., Kane, J.P.: Primary dysbetalipoproteinemia — Predominance of a specific apoprotein in triglyceride-rich lipoproteins. Proc. Nat. Acad. Sci. U.S. 70, 2015 (1973)
Havel, R.J., Shore, V.G., Shore, B., Bier, D.H.: Role of specific glycopeptides of human serum lipoproteins in the activation of lipoprotein lipase. Circ. Res. 27, 595 (1970)
Hosoda, Y., Suzuki, M.: Production of atherosclerosis in lathyric aortas of rats. Path. Microbiol. 35, 267 (1970)
Julian, M., Fabre, M.Th., Bouissou, H.: Lathyrisme expérimental. Modifications simultanées des tissus conjonctifs cutanés et aortiques. Path. et Biol. 19 (7–8), 389–399 (1971)
Julian, M., Pieraggi, M.Th., Bouissou, H.: Lathyrisme et régime athérogène chez le rat. Path et Biol. 20, 23–26, 951–959 (1972)
Julian, M., Pieraggi, M.Th., Bouissou, H.: Lathyrisme chronique. Modèle expérimental du vieillissement du tissu conjonctif humain. Gerontologia 9, 220–239 (1973)/Experientia 30, 210 (1974)
Julian, M., Pieraggi, M.Th., Bouissou, H.: Lathyrisme chronique. Régime hyperlipidique prolongé et athérome chez le rat. Path. et Biol. 24, 355–358 (1976)
Kane, B.J.: A rapid electrophoretic technique for identification of apoproteins and serum lipoproteins. Ann. Biochem. 53, 350 (1973)
Lasser, N.L., Roheim, P.S., Edelstein, D., Eder, H.A.: Serum lipoproteins of normal and cholesterol fed rats. J. Lipid. Res. 14, 1–8 (1973)
Lieberman, C.: Ueber das oxychinoterpey. Berichte 18, 1803 (1885)
Narayan, K.A., Creinin, H.L., Kummerow, F.D.: Disc electrophoresis of rat plasma lipoproteins. J. Lipid. Res. 7, 150–157 (1966)
Rodriguez, J.L., Ghiselli, G.C., Torreggiani, D., Sirtori, C.R.: Very low density lipoproteins in normal and cholesterol fed rabbits: lipid and protein composition and metabolism. Part I (Chemical composition of very low density lipoproteins in rabbits). Atherosclerosis 23, 73–83 (1976)
Rodriguez, J., Catapano, A., Ghiselli, G.C., Sirtori, C.R.: Turnover and aortic uptake of very low density lipoproteins (V.L.D.L.) from hypercholesterolemic rabbits as a model for testing antiatherosclerotics compounds. Adv. Exp. Med. Biol. 67, 169–189 (1976)
Rose, H.G., Oklander, M.J.: Improved procedure for the extraction of lipids from human erythrocytes. J. Lipid. Res. 6, 428 (1965)
Scanu, A.M., Aggerbeck, L.P., Kruski, A.W., Lim, C.T., Kayden, H.J.: A study of the abnormal lipoproteins in abetalipoproteinemia. J. Clin. Invest. 53, 440 (1974)
Selye, H.: Lathyrism. Revue Canadienne de Biologie 16, 3–82 (1975)
Shore, V.G., Shore, B., Hart, R.G.: Changes in apolipoproteins and properties of rabbits very low density lipoproteins on induction of cholesterolemia. Biochemistry 13, 1579–1584 (1974)
Author information
Authors and Affiliations
Additional information
Supported by Centre National Recherche Scientifique — E.R.A. Nℴ 499.
Rights and permissions
About this article
Cite this article
Bouissou, H., Thiers, J.C., Douste-Blazy, L. et al. Chronic lathyrism and atheromatosis in the rat. Virchows Arch. A Path. Anat. and Histol. 380, 107–117 (1978). https://doi.org/10.1007/BF00430617
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00430617