Abstract
Effects of injections of two doses of nicotine (0.2 and 0.4 mg/kg body wt) were tested on general activity (in a photocell chamber) and on locomotor activity (in an activity wheel) in male and female rats of two ages (40 and 90 days). Behavior was monitored under light and dark conditions at 15, 30, and 45 min post-injection over a period of 12 days. A general excitatory effect of nicotine was observed in the photocell chamber, with the high dosage greatly increasing activity for younger and female animals. In the activity wheel an initial depressant effect was observed followed by excitation at the lower dose. No evidence for tolerance or difference between light and dark test conditions was found.
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References
Bovet D, Bovet-Nitti F, Oliverio A (1967) Action of nicotine on spontaneous and acquired behavior in rats and mice. Ann N Y Acad Sci USA 142:261–267
Erickson CK (1971) Studies on the mechanism of avoidance facilitation by nicotine. Psychopharmacologia 22:357–368
Guha D, Pradhan SN (1976) Effects of nicotine on EEG and evoked potentials and their intractions with autonomic drugs. 15:225–232
Hatchell PLC (1976) The pharmacological and behavioral affects of nicotine in inbred mice (Doctoral dissertation, University of Pennsylvania). Dissertation Abstracts Internations 37:1521B-1522B
Hubbard JE, Gohd R (1975) Tolerance development to the arousal effects of nicotine, Pharmacol Biochem Behav 3:471–476
Larson PS, Silvette H (1965) Tobacco alkaloids and central nervous system functions. In: Von Euler US (ed) Tobacco, alkaloids and related compounds. Macmillan, New York, pp 105–124
Meliska CJ, Fitzpatrick KW, Rosine JE (1974) Effects of nicotine on spontaneous locomotor activity in rats having high and low basal activity lovels. Physiol Psychol 2:487–489
Morrison CF (1969) Effects of nicotine on motor co-ordination and spontaneous activity in mice. J Pharm Pharmacol 21:35–37
Morrison CF, Stephenson JA (1972) The occurrence of tolerance to a central depressant effect of nicotine. Br J Pharmacol 45:151–156
Silvette H, Hoff EC, Larson PS, Haag HB (1962) The action of nicotine on central nervous system functions. Pharmacol Rev 14:137–173
Stolerman IP, Bunker P, Jarvik ME (1974) Nicotine tolerance in rats: role of dose and dose interval. Psychopharmacologia 34:317–325
Van Rossum JM (1962) Cumulative record of motor activity (a new procedure and its use for the study of central stimulant drugs). Experientia 18:93–96
Wenzel DG, Broadie LL (1966) Effects of group size and cage design on voluntary running activity of amphetamine-treated mice. Arch Int Pharmacodyn 159:154–160
Yamamoto KI, Komino EF (1965) Nicotine induced EEG and behavioral arousal. Int J Neuropharmacol 4:359–373
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Bryson, R., Biner, P.M., McNair, E. et al. Effects of nicotine on two types of motor activity in rats. Psychopharmacology 73, 168–170 (1981). https://doi.org/10.1007/BF00429211
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DOI: https://doi.org/10.1007/BF00429211