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Inhibition of Coprinus cinereus by 5-fluoroindole

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Abstract

5-Fluoroindole (5FI) was more inhibitory than 5-fluorotryptophan (5FT) to Coprinus cinereus. A mutant blocked in the conversion of indole to tryptophan, but not one blocked earlier in the tryptophan pathway, was resistant to 5FI. This is consistent with the hypothesis that 5FI was converted in vivo to 5FT which inhibited growth.

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Abbreviations

5FT:

5-fluoro-DL-tryptophan

5FI:

5-fluoroindole

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Author notes

  1. Michael J. Tilby

    Present address: Physics Department Block F, Institute of Cancer Research, Clifton Avenue, SM2 5PX, Sutton, Surrey, England

Authors and Affiliations

  1. Department of Plant Biology and Microbiology, Queen Mary College, Mile End Road, El 4NS, London, England

    Michael J. Tilby

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  1. Michael J. Tilby
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Tilby, M.J. Inhibition of Coprinus cinereus by 5-fluoroindole. Arch. Microbiol. 118, 301–303 (1978). https://doi.org/10.1007/BF00429121

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  • DOI: https://doi.org/10.1007/BF00429121

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