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Failure of antiserotonergic agents to modify levallorphan-induced stereotypy in rats

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Abstract

The possibility that the stereotypic behaviour induced by levallorphan, a narcotic antagonist, might be influenced by a serotonergic system was examined. Two antiserotonergic agents, methysergide and parachlorophenylalanine, failed to modify such stereotypy implying that serotonin is not involved. It is suggested that dopamine might be the principal mediator of this behaviour.

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Author notes

  1. Samuel R. Wray

    Present address: Dept. of Psychiatry, University of the West Indies, Mona, Kingston 7, Jamaica, WI

Authors and Affiliations

  1. Department of Psychology, University of Hull, England

    Keith C. Phillips & Samuel R. Wray

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  1. Keith C. Phillips
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  2. Samuel R. Wray
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Supported by a grant from the Science Research Council.

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Phillips, K.C., Wray, S.R. Failure of antiserotonergic agents to modify levallorphan-induced stereotypy in rats. Psychopharmacologia 41, 263–265 (1975). https://doi.org/10.1007/BF00428934

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  • DOI: https://doi.org/10.1007/BF00428934

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