Abstract
Common marmosets (Callithrix jacchus) were trained to perform daily position discrimination learning tasks in a Wisconsin General Test Apparatus. Acetylcholine receptor blockade with scopolamine was found to impair position learning. Testing on the day after scopolamine treatment suggested that a task learnt under scopolamine was not encoded into long term memory. Acetylcholine depletion achieved by the intraventricular injection of hemicholinium 4 h before testing resulted in a profound impairment of position discrimination learning. It is suggested that central acetylcholine depletion in primates may provide a useful model of senile dementia.
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Ridley, R.M., Barratt, N.G. & Baker, H.F. Cholinergic learning deficits in the marmoset produced by scopolamine and ICV hemicholinium. Psychopharmacology 83, 340–345 (1984). https://doi.org/10.1007/BF00428542
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DOI: https://doi.org/10.1007/BF00428542