Abstract
In order to studh the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy.
The EEG changes induced by apomorphine administration in comparison to those elicited by promazine or placebo were evaluated in a double blind cross-over study. Similarly to promazine treatment, apomorphine worsened the EEG recordings of some patients. The apomorphine-induced increase in paroxysmal activity was observed in patients affected by partial epilepsy and was not related to the sleep-inducing properties of the drug.
This effect is interpreted as being the result of a stimulation of DA autoreceptors, mediating a decrease of dopaminergic activity in the central nervous system. The use of apomorphine as an EEG activating agent is suggested.
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References
Andèn NE, Butcher SA, Corrodi H, Fuxe H, Ungerstedt U (1970) Receptor activity and turnover of dopamine, and noradrenaline after after neuroleptics. Eur J Pharmacol 11:303–314
Anzelark G, Meldrum B (1978) Blockade of photically induced epilepsy by dopamine agonist ergot alkaloids. Psychopharmacology 57:57–62
Anzelark G, Horton RW, Meldrum B (1976) Dopamine agonists and reflex epilepsy. In: Roberts PJ, Woodruff GN, Iversen LL (eds) Dopamine. Raven Press, New York, pp 383–388
Boggan WO, Seiden LS (1971) DOPA reversal of reserpine enhancement of audiogenic seizure susceptibility in mice. Physiol Behav 6:215–217
Borenstein P, Dabbh M, Blés G (1962) Etude électroencéphalographique de l'halopéridol. Ann Med Psychol 120:133–136
Borkowski WI, Kohlmeyer K (1959) Convulsive seizures under promazine medication. Virginia Med Mth 86:213–216
Bunney BS, Aghajanian GK (1975) Evidence for drug actions on both pre- and postsynaptic catecholamine receptors in the CNS. In: Jusdin E, Bunney WE Jr (eds) Pre- and postsynaptic receptors. Dekker, New York, pp 89–122
Carlsson A, Fuxe K, Hamberger B, Lindquist M (1966) Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamines neurones. Acta Physiol Scand 67:481–497
Carlsson A (1975) Receptor-mediated control of dopamine metabolism. In: Jusdin E, Bunney WE Jr (eds) Pre- and postsynaptic receptors. Dekker, New York, pp 49–65
Corsini GU, Del Zompo M, Manconi S, Piccardi MP, Onali PL, Mangoni A, Gessa GL (1977a) Evidence for dopamine receptors in the human brain mediating sedation and sleep. Life Sci 20:1613–1618
Corsini GU, Del Zompo M, Manconi S, Cianchetti C, Mangoni A, Gessa GL (1977b) Sedative, hypnotic and antipsychotic effect of low doses of apomorphine in man. In: Gessa GL, Costa E (eds) Nonstriatal dopaminergic neurons. Raven, New York, pp 645–648
Corsini GU, Onali PL, Masala C, Mangoni A, Gessa GL (1978) Apomorphine hydrochloride-induced improvement in Huntington's Chorea. Arch Neurol 35:27–30
Corsini GU, Bernardi F, Marrosu F, Gessa GL (1980) Neuropsychiatric implications of drugs acting on dopamine receptors: the effect of apomorphine. In: Battistin L, Hashim G, Lajtha A (eds) Neurochemistry and clinical neurology. Alan Liss Inc., New York pp 225–237
Dongier S, Dongier M, Faidherbe J, Gastaut H (1961) Essai de l'haloperidol dans les troubles mentaux des enfants épileptiques. Presse Med 69:1191
Ernst AM (1967) Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia 10:316–323
Fazekas JF, Shea JG, Ehrmantraut WR et al. (1957) Convulsant action of phenothiazine derivatives. JAMA 165:1241–1245
Gastaut H (1970) Clinical and electroencephalographical classification of epileptic seizures. Epilepsia 11:102–113
Gloor P, Twai C, Haddad F (1958) An assessment of the value of sleep-electroencephalography for the diagnosis of temporal lobe epilepsy. Electroencephalogr Clin Neurophysiol 10:633–648
Innes IR, Nickerson M (1975) Norepinephrine, epinephrine and the sympathomimetic amines. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 5th ed. Macmillan, New York, pp 497
Itil TM, Cannon P, Hsu W et al. (1970) Digital computer analyzed sleep and resting EEG during haloperidol treatment. Am J Psychiatry 127:462
Janssen PAJ, Niemeegers CJE, Schellekens KHL (1965) Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? Neuroleptic activity spectra for rats. Arzneim Forsch 15:104
Kilian M, Frey HH (1973) Central monoamines and convulsive thresholds in mice and rats. Neuropharmacology 12:681–692
Kohsaka M, Hiramatsu M, Mori A (1978) Brain catecholamine concentrations and convulsions in El mice. In: Roberts PJ, Woodruff GN, Iversen LL (eds) Dopamine. Raven, New York, pp 389–392
Lyberi G, Last SL (1956) The use of chlorpromazine as an activating agent. Electroencephalogr Clin Neurophysiol 8:711–712
Mason ST, Corcoran ME (1979) Catecholamines and convulsion. Brain Res 170:497–507
Meldrum B, Anzelark G (1975) Effects of apomorphine ergocornine and piribedil on audiogenic seizures in DBA/2 mice. Br J Pharmacol 53:419–424
Meldrum B, Anzelark G, Trimble M (1975) Drugs modifying dopaminergic activity and behaviour, the EEG and epilepsy in Papio-Papio. Eur J Pharmacol 32:203–213
Merlis JK, Grossman C, Henriksen GF (1951) Comparative effectiveness of sleep and metrazol-activated electroencephalography. Electroencephalogr Clin Neurophysiol 3:71–78
Niedermeyer E (1965) Sleep electroencephalograms in Petit Mal. Arch Neurol 12:625–630
Niedermeyer E (1966) Generalized seizure discharges and possible precipitating mechanisms. Epilepsia 7:23–28
Simons AJR (1958) EEG-activation by means of chlorpromazine. Electroencephalogr Clin Neurophysiol 10:356
Stewart LF (1957) Chlorpromazine: used to activate electroencephalographic seizure patterns. Electroencephalogr Clin Neurophysiol 9:427–440
Tamminga CA, Schaffer MH, Smith RC et al. (1978) Schizophrenic symptoms improve with apomorphine. Science 200:567–568
Tolosa ES, Sparber SB (1974) Apomorphine in Huntington's Chorea: clinical observations and theoretical considerations. Life Sci 15:1371–1380
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Del Zompo, M., Tocco, F., Marrosu, F. et al. Increased paroxysmal activity of partial seizures in man by apomorphine. Psychopharmacology 79, 209–214 (1983). https://doi.org/10.1007/BF00427814
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DOI: https://doi.org/10.1007/BF00427814