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The effects of diphenylhydantoin on rat behavior

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Abstract

Animals were administered increasing doses of diphenylhydantoin (DPH) for 20 days. During withdrawal they were observed in an open field. The results suggest that chronic DPH administration leads to a central supersensitivity phenomenon. Possible interference of DPH with dopaminergic systems was discussed.

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Author notes

  1. T. C. M. De Lima

    Present address: Department of Pharmacology, Faculty of Medicine, University of Santa Catarina, Florianópolis, SC, Brazil

Authors and Affiliations

  1. Laboratory of Therapeutics, Faculty of Veterinary Medicine, University of São Paulo, São Paulo, Brazil

    T. C. M. De Lima & J. Palermo Neto

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  1. T. C. M. De Lima
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  2. J. Palermo Neto
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De Lima, T.C.M., Palermo Neto, J. The effects of diphenylhydantoin on rat behavior. Psychopharmacology 69, 183–185 (1980). https://doi.org/10.1007/BF00427647

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  • DOI: https://doi.org/10.1007/BF00427647

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