Abstract
Previously acquired continuous avoidance performance of pigs in a shuttle-box was modified by a Pavlovian fear-conditioning procedure. Diazepam (1 mg/kg) given before the Pavlovian conditioning session prevented the increase in corticosteroids and the impairment of performance in the subsequent test session before the presentation of the fear signal. Diazepam given before the Pavlovian conditioning session and/or the test session did not prevent the increase of response to the CS presentation; however, the temporal pattern of increase differed according to the drug condition: the diazepam treatment on the day of the test significantly delayed the peak of responding to the CS; in pigs treated with diazepam on the day of Pavlovian conditioning and with saline on the day of test, the increase of response was diffuse instead of being localized to the CS presentation period. Pigs treated with diazepam both during learning and performance of fear conditioning showed some evidence of performance facilitation. Usual unitary interpretations cannot account for such results which would appear to be the net result of several intermingled effects among which state-dependent learning, acquisition deficit, and performance facilitation seem to be of importance.
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References
Anisman, H.: Time-dependent variations in aversively motivated behaviors: nonassociative effects of cholinergic and catecholaminergic activity. Psychol. Rev. 82, 359–385 (1975)
Bassett, J. R., Cairncross, K. D.: Effects of psychoactive drugs on responses of the rat to aversive stimulation. Arch. int. Pharmacodyn. 212, 221–229 (1974)
Chisholm, D. C., Moore, J. W.: Effects of chloriiazepoxide on discriminative fear conditioning and shuttle avoidance performance in the rabbit. Psychopharmacologia (Berl.) 18, 162–171 (1970)
Cicala, G. A., Hartley, D. L.: The effects of chlordiazepoxide on the acquisition and performance of a conditioned escape response in rats. Psychol. Rec. 15, 435–440 (1965)
Dantzer, R., Mormede, P.: Fear-dependent variations in continuous avoidance behaviour of pigs. I. Lack of effect of diazepam on performance of discriminative fear conditioning. Psychopharmacology 49:69–73 (1976)
Feldman, R. S.: The mechanism of fixation prevention and “dissociation” learning with chlordiazepoxide. Psychopharmacologia (Berl.) 12, 384–399 (1968)
Galen, F. X., Pesquies, P., Menard, J., Corvol, P.: Excretion des stéroïdes parotidiens en relation avec les variations de la cortisolémie. Ann. Biol. clin. 31, 459–465 (1973)
Houser, V. P., Paré, W. P.: Analgesic potency of sodium salicylate, indomethacin and chlordiazepoxide as measured by the spatial preference technique in the rat. Psychopharmacologia (Berl.) 32, 121–131 (1973)
Houser, V. P., Rothfeld, B., Varady, A., Jr.: Effects of chlordiazepoxide upon fear-motivated behavior in dogs. Psychol. Rep. 36, 987–998 (1975)
Krulik, R., Cerny, M.: Effect of chlordiazepoxide on stress in rats. Life Sci. 10, 145–151 (1971)
Maier, S. F., Seligman, M. E. P., Solomon, R. L.: Pavlovian fear conditioning and learned helplessness: effects on escape and avoidance behavior of (a) the CS-US contingency and (b) the independence of the US and voluntary responding. In: Punishment and aversive behavior, B. A. Campbell and R. M. Church, eds., pp. 299–342. New York: Appleton-Century-Crofts 1969
Murphy, B. E. P.: Some studies on the protein-binding on the steroids and their application to the routine micro-and ultramicro-measurement. J. clin. Endocr. 27, 973–977 (1967)
Overton, D. A.: Experimental methods for the study of statedependent learning. Fed. Proc. 33, 1800–1813 (1974)
Scobie, S. R., Garske, G.: Chlordiazepoxide and conditioned suppression. Psychopharmacologia (Berl.) 16, 272–280 (1970)
Stein, L., Berger, B. D.: Paradoxical fear-increasing effects of tranquilizers: evidence of repression of memory in the rat. Science 166, 253–256 (1969)
Weiss, J. M., Glazer, H. I.: Effects of acute exposure to stressors on subsequent avoidance-escape behavior. Psychosom. Med. 37, 499–521 (1975)
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Dantzer, R., Mormede, P. & Favre, B. Fear-dependent variations in continuous avoidance behavior of pigs. Psychopharmacology 49, 75–78 (1976). https://doi.org/10.1007/BF00427474
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DOI: https://doi.org/10.1007/BF00427474