Abstract
The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of apomorphine to the dopamine receptors.
The effects of thymoleptics on elements of animal behavior that can be associated with brain dopamine appear interesting on the background of a considerable body of evidence indicating an association of brain dopamine with depression and mania (references).
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Andén, N.-E., Corrodi, H., Fuxe, K., Hökfelt, B., Hökfelt, T., Rydin, C., Svensson, T.: Evidence for a central noradrenaline receptor stimulation by clonidine. Life Sci. 9, 513–523 (1970)
Braestrup, C., Nielsen, M.: Regulation in the central norepinephrine neurotransmission induced in vivo by α-adrenoceptor active drugs. J. Pharmacol. exp. Ther. (in press)
Christensen, A. V., Møller Nielsen, I.: Influence of flupenthixol and flupenthixol-decanoate on methylphenidate and apomorphine-induced compulsive gnawing in mice. Psychopharmacologia (Berl.) 34, 119–126 (1974)
Costall, B., Naylor, R. J.: Possible involvement of noradrenergic area of the amygdala with stereotyped behaviour. Life Sci. 11, 1135–1146 (1972)
Fjalland, B., Møller Nielsen, I.: Enhancement of methylphenidate-induced stereotypies by repeated administration of neuroleptics. Psychopharmacologia (Berl.) 34, 105–109 (1974)
Halaris, A. E., Belendiuk, K., Freedman, D. X.: Antidepressant drugs affect dopamine uptake. Biochem. Pharmacol. 24, 1896–1898 (1975)
Kadzielawa, K., Popielarski, M.: Potentiation by desipramine of the pressor and depressor effects of dopamine. J. Pharm. Pharmacol. 23, 550–551 (1971)
Karobath, M. E.: Tricyclic antidepressive drugs and dopamine-sensitive adenylate cyclase from rat brain striatum. Europ. J. Pharmacol. 30, 159–163 (1975)
Lassen, J., Buus, Petersen, E., Kjellberg, B., Olsson, S. O.: Comparative studies of a new 5HT-uptake inhibitor and some tricyclic thymoleptics. Europ. J. Pharmacol. 32, 108–115 (1975a)
Lassen, J., Buus, Squires, R. F., Christensen, J. A., Molander, L.: Neurochemical and pharmacological studies on a new 5HT-uptake inhibitor, FG 4963, with potential antidepressant properties. Psychopharmacologia (Berl.) 42, 21–26 (1975b)
Maj, J., Pawlowski, L., Wiszniowska, G.: The effect of tricyclic antidepressants on apomorphine-induced hypothermia in the mouse. Pol. J. Pharmacol. Pharm. 26, 329–336 (1974)
Menge, H. G., Brand, U.: Untersuchungen über die Stereotypien nach Amphetamin and Apomorphine sowie deren pharmakologische Beeinflussung. Psychopharmacologia (Berl.) 21, 212–228 (1971)
Mogilnicka, E., Braestrup, C.: Noradrenergic influence on the stereotyped behaviour induced by amphetamine, phenethylamine and apomorphine. J. Pharm. Pharmacol. 28, 253–255 (1976)
Molander, L., Randrup, A.: Investigation of the mechanism by which L-Dopa induces gnawing in mice. Acta pharmacol. (Kbh.) 34, 312–324 (1974)
Molander, L., Randrup, A.: Effects of thymoleptics on behaviour associated with changes in brain dopamine. I. Potentiation of Dopa-induced gnawing of mice. Psychopharmacologia (Berl.) 45, 261–265 (1976)
Neumayer, E., Riederer, P., Danielsczyk, W., Seeman, D.: Biochemische Hirnbefunde bei endogener Depression. Wien. med. Wschr. 125, 344–349 (1975)
Nielsen Møller, I., Nymark, M., Hougs, W., Pedersen, V.: The pharmacological properties of Melitracen (N 7001) and Litracen (N 7049). Arzneimittel-Forsch. 16, 135–140 (1966)
Pedersen, V.: Potensering af apomorfineffekt (tvangsgnaving) på mus. Manuscript, Lecture, Nordisk Farmakologmøde, Copenhagen 1967a
Pedersen, V.: Potentiation of apomorphine effect (compulsive gnawing behaviour) in mice. Lecture at Nordisk Farmakologmøde 1967. Abstract. Acta pharmacol. (Kbh.) 25, Suppl. 4, 63 (1967b)
Pedersen, V.: Role of catecholamines in compulsive gnawing behaviour in mice. Brit. J. Pharmacol. 34, 219P-220P (1968)
Persson, T.: Drug induced changes in 3H-catecholamine accumulation after 3H-tyrosine. Acta pharmacol. (Kbh.) 28, 378–390 (1970)
Randrup, A., Munkvad, I., Fog, R., Gerlach, J., Molander, L., Kjellberg, B., Scheel-Krüger, J.: Mania, depression and brain dopamine. In: Current developments in psychopharmacology, vol. 2. New York: Spectrum Publ. 1975a
Randrup, A., Munkvad, I., Fog, R., Ayhan, I. H.: Catecholamines in activation stereotypy and level of mood. In: Catecholamines and behavior. I. A. J. Friedhoff, ed., pp. 89–107. New York: Plenum Press 1975
Rochette, L., Bralet, J.: Effect of clonidine on the synthesis of cerebral dopamine. Biochem. Pharmacol. 24, 303–305 (1975)
Roffler-Tarlov, S.: Differences between the effects of acute long-term treatment with desmethylimipramine on reserpine-induced release of amines from rat brain. Biochem. Pharmacol. 24, 1321–1325 (1975)
Scheel-Krüger, J.: Central effects of anticholinergic drugs measured by the apomorphine gnawing test in mice. Acta pharmacol. (Kbh.) 28, 1–16 (1970)
Scheel-Krüger, J., Mogilnicka, E.: Evidence for the involvement of serotonergic mechanisms of stereotypy induced by dopaminergic stimulating drugs in the rat. Abstracts. Vth Congress of the Polish Pharmacological Society, September 24–27. J. Wojcecki, ed. Poland: Szczecin 1975
Ther, L., Schramm, H.: Apomorphine-synergismus (Zwangsnagen bei Mäusen) als Test zur Differenzierung psychotroper Substanzen. Arch. int. Pharmacodyn. 138, 302–310 (1962)
Weiner, W., Goetz, C., Klawans, H.: Serotonergic and antiserotonergic influences on apomorphine induced stereotyped behaviour. Acta pharmacol. (Kbh.) 36, 155–160 (1975)
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Molander, L., Randrup, A. Effects of thymoleptics on behavior associated with changes in brain dopamine. Psychopharmacology 49, 139–144 (1976). https://doi.org/10.1007/BF00427282
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DOI: https://doi.org/10.1007/BF00427282