Abstract
Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the antischizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenalinesensitive cyclic AMP accumulation.
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Reches, A., Ebstein, R.P. & Belmaker, R.H. The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. Psychopharmacology 58, 213–216 (1978). https://doi.org/10.1007/BF00426910
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DOI: https://doi.org/10.1007/BF00426910