Abstract
Previously we demonstrated an approximately 20% loss of nerve cells in the basal ganglia of rats following treatment with perphenazine enanthate 3.4 mg/kg s.c. every 2nd week during 12 months. If the treatment period was only 2 or 3 months no significant differences were found.
In the present investigation a treatment period of 6 months and a 10-fold higher dose of perphenazine enanthate (40 mg/kg s.c. every 2nd week) was used. No significant differences from control animals were found by cell counting in the basal ganglia and the cortex, by electron microscopy investigation of the same structures, or by quantitative immunoelectrophoresis of proteins from the corpus striatum and the cortex. The uptake of 3H-uridine measured by autoradiography in the cortex and in the liver was, however, 20–50% higher in the experimental group.
The influences of dose level, duration of treatment period, and animal age are discussed and correlated to the clinical syndrome of tardive dyskinesia seen in patients treated with neuroleptics.
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Eog, R., Pakkenberg, H., Juul, P. et al. High-dose treatment of rats with perphenazine enanthate. Psychopharmacology 50, 305–307 (1976). https://doi.org/10.1007/BF00426849
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DOI: https://doi.org/10.1007/BF00426849