Abstract
In eight monkeys (Cercopithecus aethiops), previously treated with haloperidol for 4–14 months, we have examined the behavioral effect of: (1) methylphenidate vs apomorphine; (2) 4,5,6,7-tetrahydroisoxazolo-(5,4-c)-pyridin-3-ol (THIP, a GABA agonist) vs diazepam; and (3) THIP and diazepam in methylphenidate-induced behavior. Methylphenidate (0.5–5.0 mg/kg) and apomorphine (0.1–0.5 mg/kg) both increased locomotion, but otherwise exhibited different behavioral profiles. Methylphenidate induced repetitive movements of head, limbs, and trunk, and hallucinatory-like behavior, but not oral hyperkinesia (licking and gnawing), whereas apomorphine preferentially caused oral hyperkinesia. THIP produced a syndrome of bradykinesia dystonia, ataxia, myoclonus, sedation, and decreased responsiveness, whereas diazepam produced only bradykinesia, ataxia, sedation, and decreased responsiveness, but not dystonia and myoclonus. Methylphenidate-induced locomotion and repetitive movements were reduced by THIP and diazepam, whereas hallucinatory-like behavior was markedly aggravated by THIP, but not by diazepam.
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Gerlach, J., Bjørndal, N. & Christensson, E. Methylphenidate, apomorphine, THIP, and diazepam in monkeys: Dopamine-GABA behavior related to psychoses and tardive dyskinesia. Psychopharmacology 82, 131–134 (1983). https://doi.org/10.1007/BF00426396
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DOI: https://doi.org/10.1007/BF00426396