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Neutralization of LSD by active immunization

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Abstract

Mice immunized with a lysergic acid derivatized protein showed subsequent resistance to the effects of intravenously administered LSD as measured by the poke and rearing tests. Mice immunized with a tryptophyl conjugated protein displayed similar refractoriness relative to normal control mice. Thus, significant immunological cross reactivity as expressed by neutralization, was evident due to the common indole moiety of the two haptenic groups studied.

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Authors and Affiliations

  1. Department of Microbiology, University of Illinois, 61801, Urbana, Illinois, USA

    Edward W. Voss Jr. & Brian B. Berger

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  1. Edward W. Voss Jr.
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  2. Brian B. Berger
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Supported by a grant from the Pharmaceutical Manufacturers Association Foundation, Inc.

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Voss, E.W., Berger, B.B. Neutralization of LSD by active immunization. Psychopharmacologia 26, 140–145 (1972). https://doi.org/10.1007/BF00422100

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  • DOI: https://doi.org/10.1007/BF00422100

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